INHBA: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. Belongs to the TGF-beta family.
Protein type: Secreted; Secreted, signal peptide
Cellular Component: extracellular space; cell; extracellular region
Molecular Function: identical protein binding; growth factor activity; protein heterodimerization activity; hormone activity; peptide hormone binding; cytokine activity; transforming growth factor beta receptor binding; receptor binding
Biological Process: positive regulation of transcription, DNA-dependent; positive regulation of cellular protein metabolic process; activin receptor signaling pathway; mesodermal cell differentiation; palate development; negative regulation of cell cycle; regulation of apoptosis; odontogenesis; negative regulation of cell proliferation; ovarian follicle development; hair follicle development; cell cycle arrest; hemoglobin biosynthetic process; response to drug; regulation of follicle-stimulating hormone secretion; positive regulation of erythrocyte differentiation; male gonad development; negative regulation of hair follicle development; progesterone secretion; regulation of transcription from RNA polymerase II promoter; mesoderm formation; regulation of MAPKKK cascade; positive regulation of transcription from RNA polymerase II promoter; hemopoietic progenitor cell differentiation; negative regulation of cell growth; cell development; G1/S transition of mitotic cell cycle; growth
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