MST1 (STK4) ELISA Kit for Human

Name: Human STK4 ELISA Kit; MST1; MyBioSource
Brand: MyBioSource
SKU: MBS824743
Price: 640 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS824743

Background: Macrophage Stimulating 1 (SMT1), also known as Hepatocyte growth factor-like protein (HGFL) and MSP, is a protein that in humans is encoded by the MST1 gene. The HGFL gene was identified at the DNF15S2 locus on human chromosome 3 (3p21). The RON… More details

$640 / 96 Tests +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

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Product Overview

Online Datasheet in PDF

Product Name

MST1 (STK4), ELISA Kit

Full Product Name

Human MST1 ELISA Kit

Product Gene Name

STK4 elisa kit

Product Synonym Names

KRS2; MST1; Serine/threonine-protein kinase 4; Mammalian STE20-like protein kinase 1; MST-1; STE20-like kinase MST1; Serine/threonine-protein kinase Krs-2

Species Reactivity

Human

Samples

Culture Supernatants, Serum, Plasma

Sensitivity

< 10 pg/ml

Specificity

The Human MST1 ELISA Kit allows for the detection and quantification of endogenous levels of natural and/or recombinant Human MST1 proteins within the range of 156 pg/ml - 10000 pg/ml.

Preparation and Storage

Shipped and store at 4 degree C for 6 months, store at -20 degree C for one year. Avoid freeze/thaw cycles.

Molecular Weight

52,335 Da

OMIM

gene 614868

3D Structure

ModBase 3D Structure for Q13043

Applications Tested/Suitable for STK4 elisa kit

Sandwich ELISA (SE)

Other Notes

Small volumes of STK4 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for STK4 purchase

MBS824743 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the MST1 (STK4) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing STK4. The ELISA analytical biochemical technique of the MBS824743 kit is based on STK4 antibody-STK4 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect STK4 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, STK4. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for STK4. It may not necessarily be applicable to this product.

NCBI GI #

5454096

NCBI GeneID

6789

NCBI Accession #

NP_006273.1

UniProt Primary Accession #

Q13043

UniProt Secondary Accession #

Q15802; Q4G156; Q5H982; Q6PD60; Q9BR32; Q9NTZ4; B2RCR8

UniProt Related Accession #

Q13043

GenBank Nucleotide #

NM_006282.2

NCBI Official Full Name

serine/threonine-protein kinase 4

NCBI Official Synonym Full Names

serine/threonine kinase 4

NCBI Official Symbol

STK4

NCBI Official Synonym Symbols

KRS2; MST1; YSK3; TIIAC

UniProt Protein Name

Serine/threonine-protein kinase 4

UniProt Synonym Protein Names

Mammalian STE20-like protein kinase 1; MST-1; STE20-like kinase MST1; Serine/threonine-protein kinase Krs-2Cleaved into the following 2 chains:Serine/threonine-protein kinase 4 37kDa subunit; MST1/N; Serine/threonine-protein kinase 4 18kDa subunit; MST1/C

Protein Family

Serine/threonine-protein kinase

UniProt Gene Name

STK4

UniProt Synonym Gene Names

KRS2; MST1; MST-1; MST1/N; MST1/C

UniProt Entry Name

STK4_HUMAN

NCBI Protein Information

serine/threonine-protein kinase 4; MST-1; STE20-like kinase MST1; mammalian sterile 20-like 1; kinase responsive to stress 2; mammalian STE20-like protein kinase 1; serine/threonine-protein kinase Krs-2; dJ211D12.2 (serine/threonine kinase 4 (MST1, KRS2))

NCBI Summary for STK4

The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process. [provided by RefSeq, Jul 2008]

UniProt Comments for STK4

MST1: a protein kinase of the STE20 family. Proteolytically activated by caspase during apoptosis. Activated by apoptotic signals as well as other stress conditions. Full activation requires both phosphorylation and caspase-mediated cleavage. Phosphorylation at serine 327 of Mst1, which is close to the caspase-3 recognition site, inhibits caspase-mediated cleavage.

Protein type: EC 2.7.11.1; Kinase, protein; Protein kinase, STE; Autophagy; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family; MST subfamily

Chromosomal Location of Human Ortholog: 20q11.2-q13.2

Cellular Component: nucleoplasm; cytoplasm; nucleus; cytosol

Molecular Function: protein dimerization activity; protein serine/threonine kinase activator activity; protein serine/threonine kinase activity; identical protein binding; protein binding; protein homodimerization activity; magnesium ion binding; transcription factor binding; ATP binding; receptor signaling protein serine/threonine kinase activity

Biological Process: central nervous system development; positive regulation of protein binding; positive regulation of apoptosis; apoptosis; protein amino acid autophosphorylation; cell morphogenesis; negative regulation of organ growth; signal transduction; protein amino acid phosphorylation; patterning of blood vessels; keratinocyte differentiation; negative regulation of cell proliferation; peptidyl-serine phosphorylation; positive regulation of fat cell differentiation; neural tube formation

Disease: T-cell Immunodeficiency, Recurrent Infections, And Autoimmunity With Or Without Cardiac Malformations

Research Articles on STK4

1. Genetic inactivation of STK4 restores YAP1 levels, triggering cell death in hematologic malignancies.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with STK4 elisa kit

Reference Product	PubMed Publications
MST1 elisa kit	>96 publications with STK4 and MST1
RASSF1 elisa kit	>15 publications with STK4 and RASSF1
CASP3 elisa kit	>14 publications with STK4 and CASP3
LATS1 elisa kit	>11 publications with STK4 and LATS1
SAV1 elisa kit	>9 publications with STK4 and SAV1
RASSF5 elisa kit	>8 publications with STK4 and RASSF5
LATS2 elisa kit	>7 publications with STK4 and LATS2
FOXO3 elisa kit	>5 publications with STK4 and FOXO3
RASSF2 elisa kit	>2 publications with STK4 and RASSF2
PRKRIR elisa kit	>1 publications with STK4 and PRKRIR

Pathways associated with STK4 elisa kit

Products by Pathway	Pathway Diagram
FoxO Signaling Pathway antibodies	FoxO Signaling Pathway Diagram
MAPK Signaling Pathway antibodies	MAPK Signaling Pathway Diagram
MAPK Signaling Pathway antibodies	MAPK Signaling Pathway Diagram
Non-small Cell Lung Cancer Pathway antibodies	Non-small Cell Lung Cancer Pathway Diagram
Non-small Cell Lung Cancer Pathway antibodies	Non-small Cell Lung Cancer Pathway Diagram
Pathways In Cancer antibodies	Pathways In Cancer Diagram
Ras Signaling Pathway antibodies	Ras Signaling Pathway Diagram
Signal Transduction Pathway antibodies	Signal Transduction Pathway Diagram
Signaling By Hippo Pathway antibodies	Signaling By Hippo Pathway Diagram

Diseases associated with STK4 elisa kit

Disease Name	Pubmed Publications
Disease Models, Animal Antibodies	>8 publications with STK4 and Disease Models, Animal
Neoplasms, Experimental Antibodies	>6 publications with STK4 and Neoplasms, Experimental
Genital Diseases, Male Antibodies	>5 publications with STK4 and Genital Diseases, Male
Liver Diseases Antibodies	>5 publications with STK4 and Liver Diseases
Prostatic Neoplasms Antibodies	>5 publications with STK4 and Prostatic Neoplasms
Liver Neoplasms Antibodies	>5 publications with STK4 and Liver Neoplasms
Lymphoma Antibodies	>5 publications with STK4 and Lymphoma
Carcinoma, Hepatocellular Antibodies	>5 publications with STK4 and Carcinoma, Hepatocellular
Lung Neoplasms Antibodies	>4 publications with STK4 and Lung Neoplasms
Adenocarcinoma Antibodies	>4 publications with STK4 and Adenocarcinoma

Organs/Tissues associated with STK4 elisa kit

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>17 publications with STK4 and Blood
Muscle Antibodies	>12 publications with STK4 and Muscle
Lung Antibodies	>9 publications with STK4 and Lung
Liver Antibodies	>7 publications with STK4 and Liver
Prostate Antibodies	>7 publications with STK4 and Prostate
Bone Antibodies	>6 publications with STK4 and Bone
Pancreas Antibodies	>4 publications with STK4 and Pancreas
Bone Marrow Antibodies	>3 publications with STK4 and Bone Marrow
Vascular Antibodies	>3 publications with STK4 and Vascular
Intestine Antibodies	>2 publications with STK4 and Intestine