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TRK A (NTRK1) ELISA Kit for Rat

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS824745

Background: Tropomyosin receptor kinase A (TrkA) are efficacious in attenuating skeletal pain. TrkA mutants were able to activate signaling cascades and were even more efficient in promoting neurite outgrowth than the wild-type receptor. TrkA is part of a… More details

$640 / 96 Tests +1 FREE 8GB USB

Product Documentation

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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
TRK A (NTRK1), ELISA Kit
Full Product Name
Rat TRK A ELISA Kit
Product Gene Name
NTRK1 elisa kit
Product Synonym Names
MTC; TRK; TRKA; High affinity nerve growth factor receptor; Neurotrophic tyrosine kinase receptor type 1; TRK1-transforming tyrosine kinase protein; Tropomyosin-related kinase A; Tyrosine kinase receptor; Tyrosine kinase receptor A; Trk-A; gp140trk; p140-TrkA
Species Reactivity
Rat
Samples
Culture Supernatants, Cell Lysates, Tissue Homogenates
Sensitivity
< 40 pg/ml
Specificity
The Rat TRK A ELISA Kit allows for the detection and quantification of endogenous levels of natural and/or recombinant Rat TRK A proteins within the range of 78 pg/ml - 5000 pg/ml.
Preparation and Storage
Shipped and store at 4 degree C for 6 months, store at -20 degree C for one year. Avoid freeze/thaw cycles.
Molecular Weight
87,252 Da
3D Structure
ModBase 3D Structure for P35739
Applications Tested/Suitable for NTRK1 elisa kit
Sandwich ELISA (SE)

Typical Testing Data/Standard Curve (for reference only) of NTRK1 elisa kit

Rat NTRK1 ELISA Kit – Cat# MBS824745

Other Notes

Small volumes of NTRK1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NTRK1 purchase

MBS824745 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the TRK A (NTRK1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing NTRK1. The ELISA analytical biochemical technique of the MBS824745 kit is based on NTRK1 antibody-NTRK1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect NTRK1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, NTRK1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for NTRK1. It may not necessarily be applicable to this product.

NCBI GI #
11024666
NCBI GeneID
59109
NCBI Accession #
NP_067600.1
UniProt Primary Accession #
P35739
UniProt Related Accession #
P35739
GenBank Nucleotide #
NM_021589.1
NCBI Official Full Name
high affinity nerve growth factor receptor
NCBI Official Synonym Full Names
neurotrophic tyrosine kinase, receptor, type 1
NCBI Official Symbol
Ntrk1
NCBI Official Synonym Symbols
Trk
UniProt Protein Name
High affinity nerve growth factor receptor
UniProt Synonym Protein Names
Neurotrophic tyrosine kinase receptor type 1; Slow nerve growth factor receptor; p140-TrkA; Trk-A
Protein Family
High affinity nerve growth factor receptor
UniProt Gene Name
Ntrk1
UniProt Synonym Gene Names
Trk; Trka; Trk-A
UniProt Entry Name
NTRK1_RAT
NCBI Protein Information
high affinity nerve growth factor receptor; trk; trk-A; p140-TrkA; TrkA neurotrophin receptor; trkA proto-oncogene receptor; tropomyosin-related kinase A; slow nerve growth factor receptor

NCBI Summary for NTRK1

a protooncogene; receptor that binds to nerve growth factor (NGF) [RGD, Feb 2006]

UniProt Comments for NTRK1

TrkA: a receptor tyrosine kinase of the Trk family. High affinity receptor for nerve growth factor, neurotrophin-3 and neurotrophin-4/5 but not brain- derived neurotrophic factor. Known substrates include Shc, PI-3K, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system. Two splice variant isoforms have been described.

Protein type: Membrane protein, integral; Protein kinase, TK; EC 2.7.10.1; Protein kinase, tyrosine (receptor); Oncoprotein; Kinase, protein; TK group; Trk family

Cellular Component: cell surface; protein complex; integral to plasma membrane; late endosome membrane; early endosome; dendrite; Golgi membrane; cell soma; early endosome membrane; axon; cytoplasm; late endosome; plasma membrane; cytoplasmic vesicle; receptor complex

Molecular Function: neurotrophin p75 receptor binding; protein binding; nerve growth factor receptor activity; protein homodimerization activity; ephrin receptor binding; protein-tyrosine kinase activity; nerve growth factor binding; transmembrane receptor protein tyrosine kinase activity; kinase binding; ATP binding

Biological Process: response to nicotine; circadian rhythm; axon guidance; mechanoreceptor differentiation; peptidyl-tyrosine phosphorylation; nerve growth factor receptor signaling pathway; protein amino acid autophosphorylation; sensory perception of pain; olfactory nerve development; positive regulation of synaptic transmission, glutamatergic; protein amino acid phosphorylation; activation of NF-kappaB transcription factor; negative regulation of cell proliferation; response to radiation; sympathetic nervous system development; learning and/or memory; response to axon injury; negative regulation of neuron apoptosis; response to electrical stimulus; detection of temperature stimulus involved in sensory perception of pain; response to hydrostatic pressure; aging; response to nutrient levels; response to drug; nervous system development; Sertoli cell development; detection of mechanical stimulus involved in sensory perception of pain; positive regulation of angiogenesis; positive regulation of programmed cell death; response to ethanol; B cell differentiation; response to activity; positive regulation of Ras protein signal transduction
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Research Articles on NTRK1

1. IGF-1 might relieve the dideoxycytidine-induced toxicity of TrkA- and TrkB-, but not TrkC-expressing dorsal root ganglion neurons.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with NTRK1 elisa kit

 Products by Pathway  Pathway Diagram
 ARMS-mediated Activation Pathway antibodies  ARMS-mediated Activation Pathway Diagram
 Activation Of TRKA Receptors Pathway antibodies  Activation Of TRKA Receptors Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Frs2-mediated Activation Pathway antibodies  Frs2-mediated Activation Pathway Diagram
 Inflammatory Mediator Regulation Of TRP Channels Pathway antibodies  Inflammatory Mediator Regulation Of TRP Channels Pathway Diagram
 Inflammatory Mediator Regulation Of TRP Channels Pathway antibodies  Inflammatory Mediator Regulation Of TRP Channels Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram

Diseases associated with NTRK1 elisa kit

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >536 publications with NTRK1 and Nervous System Diseases
 Pain Antibodies  >305 publications with NTRK1 and Pain
 Neuroblastoma Antibodies  >231 publications with NTRK1 and Neuroblastoma
 Inflammation Antibodies  >155 publications with NTRK1 and Inflammation
 Nerve Degeneration Antibodies  >128 publications with NTRK1 and Nerve Degeneration
 Necrosis Antibodies  >92 publications with NTRK1 and Necrosis
 Cardiovascular Diseases Antibodies  >60 publications with NTRK1 and Cardiovascular Diseases
 Glioma Antibodies  >54 publications with NTRK1 and Glioma
 Neoplasms, Experimental Antibodies  >52 publications with NTRK1 and Neoplasms, Experimental
 Hereditary Sensory and Autonomic Neuropathies Antibodies  >51 publications with NTRK1 and Hereditary Sensory and Autonomic Neuropathies

Organs/Tissues associated with NTRK1 elisa kit

 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >2752 publications with NTRK1 and Nerve
 Brain Antibodies  >1174 publications with NTRK1 and Brain
 Dorsal Root Ganglion Antibodies  >351 publications with NTRK1 and Dorsal Root Ganglion
 Eye Antibodies  >118 publications with NTRK1 and Eye
 Adrenal Gland Antibodies  >42 publications with NTRK1 and Adrenal Gland
 Prostate Antibodies  >41 publications with NTRK1 and Prostate
 Uncharacterized Tissue Antibodies  >2 publications with NTRK1 and Uncharacterized Tissue
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