Il-18bp (IL18BP) ELISA Kit for Human

Name: Human IL18BP ELISA Kit; Il-18bp; MyBioSource
Brand: MyBioSource
SKU: MBS824835
Price: 640 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS824835

Sandwich ELISA for quantitative detection of Human IL-18BP concentrations. More details

$640 / 96 Tests +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Request Current Manual

Product Overview

Online Datasheet in PDF

Product Name

IL-18BP (IL18BP), ELISA Kit

Full Product Name

Human IL-18BP ELISA Kit

Product Gene Name

IL18BP elisa kit

Product Synonym Names

IL18BP; Interleukin-18-binding protein; IL-18BP; Tadekinig-alfa

Species Reactivity

Human

Assay Type

Sandwich

Samples

Cell Culture Supernatants, Serum, Plasma, Urine

Detection Range

93.7 pg/ml - 6000 pg/ml

Sensitivity

10 pg/ml

Preparation and Storage

Shipped and store at 4 degree C for 6 months, store at -20 degree C for one year. Avoid freeze/thaw cycles.

Molecular Weight

17,478 Da

OMIM

604113

3D Structure

ModBase 3D Structure for O95998

Detection Method

Colorimetric

Applications Tested/Suitable for IL18BP elisa kit

Sandwich ELISA (SE)

Other Notes

Small volumes of IL18BP elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL18BP purchase

MBS824835 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the IL-18BP (IL18BP) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing IL18BP. The ELISA analytical biochemical technique of the MBS824835 kit is based on IL18BP antibody-IL18BP antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect IL18BP antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, IL18BP. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for IL18BP. It may not necessarily be applicable to this product.

NCBI GI #

89111125

NCBI GeneID

10068

NCBI Accession #

NP_001034748.1

UniProt Primary Accession #

O95998

UniProt Secondary Accession #

O95993; O96027; Q9NZA9; Q9UBR7; B3KUZ0; B7WPK4

UniProt Related Accession #

O95998

GenBank Nucleotide #

NM_001039659.1

NCBI Official Full Name

interleukin-18-binding protein isoform a

NCBI Official Synonym Full Names

interleukin 18 binding protein

NCBI Official Symbol

IL18BP

NCBI Official Synonym Symbols

IL18BPa

UniProt Protein Name

Interleukin-18-binding protein

UniProt Synonym Protein Names

Tadekinig-alfa

Protein Family

Interleukin-18-binding protein

UniProt Gene Name

IL18BP

UniProt Synonym Gene Names

IL-18BP

UniProt Entry Name

I18BP_HUMAN

NCBI Protein Information

interleukin-18-binding protein; IL-18BP; tadekinig-alfa; MC51L-53L-54L homolog gene product

NCBI Summary for IL18BP

The protein encoded by this gene functions as an inhibitor of the proinflammatory cytokine, IL18. It binds IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses. This protein is constitutively expressed and secreted in mononuclear cells. Elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]

UniProt Comments for IL18BP

IL18BP: Isoform A binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: extracellular space; extracellular region

Molecular Function: receptor antagonist activity; interleukin-18 binding

Biological Process: T-helper 1 type immune response; response to lipopolysaccharide

Research Articles on IL18BP

1. HPV16 E7 oncoprotein increases production of the IL18BP in keratinocytes.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with IL18BP elisa kit

Reference Product	PubMed Publications
IL18 elisa kit	>19 publications with IL18BP and IL18
IL18RAP elisa kit	>2 publications with IL18BP and IL18RAP
CASP1 elisa kit	>2 publications with IL18BP and CASP1
CXCL10 elisa kit	>2 publications with IL18BP and CXCL10
IFNG elisa kit	>1 publications with IL18BP and IFNG

Diseases associated with IL18BP elisa kit

Disease Name	Pubmed Publications
Heart Diseases Antibodies	>5 publications with IL18BP and Heart Diseases
Inflammation Antibodies	>3 publications with IL18BP and Inflammation
Hypertrophy Antibodies	>2 publications with IL18BP and Hypertrophy
Necrosis Antibodies	>2 publications with IL18BP and Necrosis
Infertility, Female Antibodies	>1 publications with IL18BP and Infertility, Female
Blood Coagulation Disorders Antibodies	>1 publications with IL18BP and Blood Coagulation Disorders
Arteriosclerosis Antibodies	>1 publications with IL18BP and Arteriosclerosis
Liver Diseases Antibodies	>1 publications with IL18BP and Liver Diseases
Drug-Induced Liver Injury Antibodies	>1 publications with IL18BP and Drug-Induced Liver Injury
Hyperplasia Antibodies	>1 publications with IL18BP and Hyperplasia

Organs/Tissues associated with IL18BP elisa kit

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>9 publications with IL18BP and Blood
Heart Antibodies	>4 publications with IL18BP and Heart
Muscle Antibodies	>3 publications with IL18BP and Muscle
Liver Antibodies	>2 publications with IL18BP and Liver
Ovary Antibodies	>2 publications with IL18BP and Ovary
Skin Antibodies	>1 publications with IL18BP and Skin
Thymus Antibodies	>1 publications with IL18BP and Thymus
Uterus Antibodies	>1 publications with IL18BP and Uterus
Spleen Antibodies	>1 publications with IL18BP and Spleen
Lung Antibodies	>1 publications with IL18BP and Lung