P Cadherin (CDH3) ELISA Kit for Human

Name: Human CDH3 ELISA Kit; P Cadherin; MyBioSource
Brand: MyBioSource
SKU: MBS824903
Price: 640 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS824903

Sandwich ELISA for quantitative detection of Human P Cadherin concentrations. More details

$640 / 96 Tests +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Request Current Manual

Product Overview

Online Datasheet in PDF

Product Name

P Cadherin (CDH3), ELISA Kit

Full Product Name

Human P Cadherin ELISA Kit

Product Gene Name

CDH3 elisa kit

Product Synonym Names

CDHP; Cadherin-3; Placental cadherin; P-cadherin

Species Reactivity

Human

Assay Type

Sandwich

Samples

Cell Culture Supernatants, Serum

Detection Range

62.5 pg/ml - 4000 pg/ml

Sensitivity

2 pg/ml

Preparation and Storage

Shipped and store at 4 degree C for 6 months, store at -20 degree C for one year. Avoid freeze/thaw cycles.

Molecular Weight

86,552 Da

OMIM

phenotype 601553

3D Structure

ModBase 3D Structure for P22223

Detection Method

Colorimetric

Applications Tested/Suitable for CDH3 elisa kit

Sandwich ELISA (SE)

Other Notes

Small volumes of CDH3 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CDH3 purchase

MBS824903 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the P Cadherin (CDH3) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing CDH3. The ELISA analytical biochemical technique of the MBS824903 kit is based on CDH3 antibody-CDH3 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect CDH3 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, CDH3. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for CDH3. It may not necessarily be applicable to this product.

NCBI GI #

14589891

NCBI GeneID

1001

NCBI Accession #

NP_001784.2

UniProt Primary Accession #

P22223

UniProt Secondary Accession #

Q05DI6; B2R6F4

UniProt Related Accession #

P22223

GenBank Nucleotide #

NM_001793.4

NCBI Official Full Name

cadherin-3 preproprotein

NCBI Official Synonym Full Names

cadherin 3, type 1, P-cadherin (placental)

NCBI Official Symbol

CDH3

NCBI Official Synonym Symbols

CDHP; HJMD; PCAD

UniProt Protein Name

Cadherin-3

UniProt Synonym Protein Names

Placental cadherin; P-cadherin

Protein Family

Protocadherin

UniProt Gene Name

CDH3

UniProt Synonym Gene Names

CDHP; P-cadherin

UniProt Entry Name

CADH3_HUMAN

NCBI Protein Information

cadherin-3; calcium-dependent adhesion protein, placental

NCBI Summary for CDH3

This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene have been associated with congential hypotrichosis with juvenile macular dystrophy. [provided by RefSeq, Jul 2008]

UniProt Comments for CDH3

CDH3: Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Interacts with CDCP1. Expressed in some normal epithelial tissues and in some carcinoma cell lines. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Motility/polarity/chemotaxis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 16q22.1

Cellular Component: cell-cell adherens junction; cytoplasm; integral to membrane; plasma membrane

Molecular Function: calcium ion binding

Biological Process: response to drug; positive regulation of insulin-like growth factor receptor signaling pathway; intercellular junction assembly and maintenance; wound healing; positive regulation of melanin biosynthetic process; Wnt receptor signaling pathway through beta-catenin; hair cycle process; negative regulation of transforming growth factor-beta2 production; retinal homeostasis; cell-cell adhesion; positive regulation of monophenol monooxygenase activity; negative regulation of catagen; visual perception; keratinization; homophilic cell adhesion; cell adhesion

Disease: Hypotrichosis, Congenital, With Juvenile Macular Dystrophy; Ectodermal Dysplasia, Ectrodactyly, And Macular Dystrophy Syndrome

Research Articles on CDH3

1. The X-dimer plays a key role in the specific cell-cell adhesion mediated by human P-cadherin.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CDH3 elisa kit

Reference Product	PubMed Publications
CDH1 elisa kit	>21 publications with CDH3 and CDH1
CTNNB1 elisa kit	>4 publications with CDH3 and CTNNB1

Pathways associated with CDH3 elisa kit

Products by Pathway	Pathway Diagram
Adherens Junctions Interactions Pathway antibodies	Adherens Junctions Interactions Pathway Diagram
Cell Adhesion Molecules (CAMs) Pathway antibodies	Cell Adhesion Molecules (CAMs) Pathway Diagram
Cell Adhesion Molecules (CAMs) Pathway antibodies	Cell Adhesion Molecules (CAMs) Pathway Diagram
Cell Junction Organization Pathway antibodies	Cell Junction Organization Pathway Diagram
Cell-Cell Communication Pathway antibodies	Cell-Cell Communication Pathway Diagram
Cell-cell Junction Organization Pathway antibodies	Cell-cell Junction Organization Pathway Diagram

Diseases associated with CDH3 elisa kit

Disease Name	Pubmed Publications
Skin Diseases Antibodies	>28 publications with CDH3 and Skin Diseases
Gastrointestinal Diseases Antibodies	>15 publications with CDH3 and Gastrointestinal Diseases
Breast Neoplasms Antibodies	>13 publications with CDH3 and Breast Neoplasms
Neoplasms, Experimental Antibodies	>4 publications with CDH3 and Neoplasms, Experimental
Adenoma Antibodies	>4 publications with CDH3 and Adenoma
Ectodermal dysplasia, ectrodactyly, and macular dystrophy Antibodies	>4 publications with CDH3 and Ectodermal dysplasia, ectrodactyly, and macular dystrophy
Inflammation Antibodies	>3 publications with CDH3 and Inflammation
Lung Neoplasms Antibodies	>3 publications with CDH3 and Lung Neoplasms
Lung Diseases Antibodies	>3 publications with CDH3 and Lung Diseases
Kidney Diseases Antibodies	>2 publications with CDH3 and Kidney Diseases

Organs/Tissues associated with CDH3 elisa kit

Organ/Tissue Name	Pubmed Publications
Skin Antibodies	>7 publications with CDH3 and Skin
Intestine Antibodies	>5 publications with CDH3 and Intestine
Lung Antibodies	>5 publications with CDH3 and Lung
Blood Antibodies	>5 publications with CDH3 and Blood
Stomach Antibodies	>4 publications with CDH3 and Stomach
Liver Antibodies	>4 publications with CDH3 and Liver
Eye Antibodies	>4 publications with CDH3 and Eye
Embryonic Tissue Antibodies	>4 publications with CDH3 and Embryonic Tissue
Thyroid Antibodies	>3 publications with CDH3 and Thyroid
Placenta Antibodies	>2 publications with CDH3 and Placenta