TRK B (NTRK2) ELISA Kit for Mouse

TrkB: a receptor tyrosine kinase of the Trk family. Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3, -4 and -5 but not nerve growth factor (NGF). Involved in the development and maintenance of the nervous system. Three splice variant isoforms have been described.

Protein type: Membrane protein, integral; Protein kinase, TK; EC 2.7.10.1; Kinase, protein; Protein kinase, tyrosine (receptor); TK group; Trk family

Cellular Component: cell surface; rough endoplasmic reticulum; cell; integral to plasma membrane; postsynaptic density; dendrite; dendritic spine; integral to membrane; terminal button; excitatory synapse; perikaryon; cytosol; postsynaptic membrane; growth cone; membrane; cell soma; axon; cytoplasm; presynaptic active zone; plasma membrane; nerve terminal; intracellular; receptor complex; endosome

Molecular Function: transferase activity; brain-derived neurotrophic factor receptor activity; neurotrophin binding; protein binding; protein homodimerization activity; ephrin receptor binding; brain-derived neurotrophic factor binding; protein-tyrosine kinase activity; transferase activity, transferring phosphorus-containing groups; nucleotide binding; kinase activity; transmembrane receptor protein tyrosine kinase activity; neurotrophin receptor activity; ATP binding; protein kinase activity

Biological Process: mechanoreceptor differentiation; retinal rod cell development; peptidyl-tyrosine phosphorylation; multicellular organismal development; protein amino acid autophosphorylation; neuron migration; regulation of neurotransmitter secretion; regulation of dendrite development; positive regulation of synaptic transmission, glutamatergic; protein amino acid phosphorylation; neuron differentiation; positive regulation of MAPKKK cascade; positive regulation of cell proliferation; oligodendrocyte differentiation; feeding behavior; negative regulation of neuron apoptosis; regulation of metabolic process; cell differentiation; vasculogenesis; neuromuscular junction development; central nervous system neuron development; nervous system development; regulation of GTPase activity; brain-derived neurotrophic factor receptor signaling pathway; regulation of protein kinase B signaling cascade; learning; positive regulation of peptidyl-serine phosphorylation; positive regulation of phosphoinositide 3-kinase cascade; peripheral nervous system neuron development; glutamate secretion; long-term memory; regulation of MAPKKK cascade; positive regulation of axonogenesis; cerebral cortex development; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway