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CATSPER1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS829269

MBS829269 is an antibody targeting CATSPER1. Reactive in Human, Mouse, Rat, Monkey. Host: Rabbit. Rabbit polyclonal antibody to CATSPER1 More details

$225 / 0.03 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CATSPER1, Polyclonal Antibody
Full Product Name
Anti-CATSPER1 Antibody
Product Gene Name
anti-CATSPER1 antibody
Product Synonym Names
Cation channel sperm-associated protein 1; CatSper1; hCatSper
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat, Monkey
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Specificity
Recognizes endogenous levels of CATSPER1 protein.
Preparation and Storage
Aliquot and store at -20°C for one year. Avoid freeze/thaw cycles.
Antibody/Peptide Pairs
CATSPER1 peptide (MBS8216061) is used for blocking the activity of CATSPER1 antibody (MBS829269)
OMIM
606389
3D Structure
ModBase 3D Structure for Q8NEC5
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human CATSPER1. The exact sequence is proprietary.
Applications Tested/Suitable for anti-CATSPER1 antibody
Western Blot (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)
Application Notes for anti-CATSPER1 antibody
WB (1/500 - 1/1000), IF/ICC (1/50 - 1/200)

Western Blot (WB) of anti-CATSPER1 antibody

Western blot analysis of CATSPER1 expression in Hela (A), DLD (B), A375 (C), mouse testis (D), rat testis (E) whole cell lysates. (Predicted band size: 90 kD; Observed band size: 110 kD)
Rabbit Anti-CATSPER1 Polyclonal Antibody – Cat# MBS829269

Immunofluorescence (IF) of anti-CATSPER1 antibody

Immunofluorescent analysis of CATSPER1 staining in SGC7901 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a hidified chamber. Cells were washed with PBST and incubated with a AF488-conjugated secondary antibody (green) in PBS at room temperature in the dark. Phalloidin - AF594 was used to stain the cytoplasm (red). DAPI was used to stain the cell nuclei (blue).
Rabbit Anti-CATSPER1 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS829269

Other Notes

Small volumes of anti-CATSPER1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CATSPER1. It may not necessarily be applicable to this product.

NCBI GI #
221316609
NCBI GeneID
117144
NCBI Accession #
NP_444282.3
UniProt Primary Accession #
Q8NEC5
UniProt Secondary Accession #
Q96P76
UniProt Related Accession #
Q8NEC5
GenBank Nucleotide #
NM_053054.3
NCBI Official Full Name
cation channel sperm-associated protein 1
NCBI Official Synonym Full Names
cation channel, sperm associated 1
NCBI Official Symbol
CATSPER1
NCBI Official Synonym Symbols
SPGF7; CATSPER
UniProt Protein Name
Cation channel sperm-associated protein 1
Protein Family
Cation channel sperm-associated protein
UniProt Gene Name
CATSPER1
UniProt Synonym Gene Names
CatSper1; hCatSper
UniProt Entry Name
CTSR1_HUMAN
NCBI Protein Information
cation channel sperm-associated protein 1

NCBI Summary for CATSPER1

Calcium ions play a primary role in the regulation of sperm motility. This gene belongs to a family of putative cation channels that are specific to spermatozoa and localize to the flagellum. The protein family features a single repeat with six membrane-spanning segments and a predicted calcium-selective pore region. [provided by RefSeq, Jul 2008]
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UniProt Comments for CATSPER1

CATSPER1: Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH. Defects in CATSPER1 are the cause of spermatogenic failure type 7 (SPGF7). An infertility disorder characterized by non-motile sperm or sperm motility below the normal threshold, low sperm count, increased abnormally structured spermatozoa, and reduced semen volume. Belongs to the cation channel sperm-associated (TC 1.A.1.19) family.

Protein type: Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11q12.1

Cellular Component: plasma membrane

Molecular Function: voltage-gated calcium channel activity; protein binding; calcium activated cation channel activity

Biological Process: sperm-egg recognition; sperm motility; fusion of sperm to egg plasma membrane; multicellular organismal development; single fertilization; spermatogenesis; regulation of calcium ion transport; cell differentiation; multicellular organism reproduction

Disease: Spermatogenic Failure 7
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Research Articles on CATSPER1

1. Sox5 and Sox9 cause a significant increase in transactivation of the Catsper1 promoter.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CATSPER1 antibody

 Reference Product  PubMed Publications
 CATSPER2 antibody  >23 publications with CATSPER1 and CATSPER2
 CATSPER3 antibody  >10 publications with CATSPER1 and CATSPER3
 CATSPER4 antibody  >8 publications with CATSPER1 and CATSPER4
 KCNU1 antibody  >8 publications with CATSPER1 and KCNU1
 CATSPERB antibody  >4 publications with CATSPER1 and CATSPERB
 HSPA2 antibody  >2 publications with CATSPER1 and HSPA2
 CACNA1I antibody  >1 publications with CATSPER1 and CACNA1I
 CATSPERG antibody  >1 publications with CATSPER1 and CATSPERG

Pathways associated with anti-CATSPER1 antibody

 Products by Pathway  Pathway Diagram
 Fertilization Pathway antibodies  Fertilization Pathway Diagram
 Reproduction Pathway antibodies  Reproduction Pathway Diagram
 Sperm Motility And Taxes Pathway antibodies  Sperm Motility And Taxes Pathway Diagram

Diseases associated with anti-CATSPER1 antibody

 Disease Name  Pubmed Publications
 Infertility, Female Antibodies  >4 publications with CATSPER1 and Infertility, Female
 Aneuploidy Antibodies  >1 publications with CATSPER1 and Aneuploidy
 Chromosome Aberrations Antibodies  >1 publications with CATSPER1 and Chromosome Aberrations
 Inflammation Antibodies  >1 publications with CATSPER1 and Inflammation

Organs/Tissues associated with anti-CATSPER1 antibody

 Organ/Tissue Name  Pubmed Publications
 Testis Antibodies  >25 publications with CATSPER1 and Testis
 Bone Antibodies  >1 publications with CATSPER1 and Bone
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