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GNL3L Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS829324

MBS829324 is an antibody targeting GNL3L. Reactive in Human, Mouse, Bovine. Host: Rabbit. Rabbit polyclonal antibody to GNL3L More details

$225 / 0.03 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
GNL3L, Polyclonal Antibody
Full Product Name
Anti-GNL3L Antibody
Product Gene Name
anti-GNL3L antibody
Product Synonym Names
Guanine nucleotide-binding protein-like 3-like protein
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Bovine
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Specificity
Recognizes endogenous levels of GNL3L protein.
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Antibody/Peptide Pairs
GNL3L peptide (MBS8218796) is used for blocking the activity of GNL3L antibody (MBS829324)
Molecular Weight
65,573 Da
OMIM
300873
3D Structure
ModBase 3D Structure for Q9NVN8
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human GNL3L. The exact sequence is proprietary.
Applications Tested/Suitable for anti-GNL3L antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-GNL3L antibody
WB (1/500 - 1/1000), IHC (1/100 - 1/200)

Western Blot (WB) of anti-GNL3L antibody

Western blot analysis of GNL3L expression in Lovo (A), HeLa (B), NIH3T3 (C) whole cell lysates.
Rabbit Anti-GNL3L Polyclonal Antibody – Cat# MBS829324

Immunohistochemistry (IHC) of anti-GNL3L antibody

Immunohistochemical analysis of GNL3L staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
Rabbit Anti-GNL3L Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS829324

Other Notes

Small volumes of anti-GNL3L antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for GNL3L. It may not necessarily be applicable to this product.

NCBI GI #
296317324
NCBI GeneID
54552
NCBI Accession #
NP_001171748.1
UniProt Primary Accession #
Q9NVN8
UniProt Related Accession #
Q9NVN8
GenBank Nucleotide #
NM_001184819.1
NCBI Official Full Name
guanine nucleotide-binding protein-like 3-like protein
NCBI Official Synonym Full Names
guanine nucleotide binding protein-like 3 (nucleolar)-like
NCBI Official Symbol
GNL3L
UniProt Protein Name
Guanine nucleotide-binding protein-like 3-like protein
Protein Family
Guanine nucleotide-binding protein-like 3-like protein
UniProt Gene Name
GNL3L
UniProt Entry Name
GNL3L_HUMAN
NCBI Protein Information
guanine nucleotide-binding protein-like 3-like protein

NCBI Summary for GNL3L

The protein encoded by this gene appears to be a nucleolar GTPase that is essential for ribosomal pre-rRNA processing and cell proliferation. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010]

UniProt Comments for GNL3L

GNL3L: Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP. Belongs to the MMR1/HSR1 GTP-binding protein family.

Protein type: Nucleolus

Chromosomal Location of Human Ortholog: Xp11.22

Cellular Component: nucleoplasm; membrane; mitochondrion; cytoplasm; nucleolus; nucleus

Molecular Function: GTPase activity; protein binding; GTP binding

Biological Process: metabolic process; ribosome biogenesis and assembly
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Research Articles on GNL3L

1. GNL3L depletion impairs ribosome production without inducing appreciable DNA damage. During evolution, GNL3L retained the role of the ancestral gene in ribosome biosynthesis, whereas the paralogous nucleostemin acquired a novel genome-protective function.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-GNL3L antibody

 Products by Pathway  Pathway Diagram
 Ribosome Biogenesis In Eukaryotes Pathway antibodies  Ribosome Biogenesis In Eukaryotes Pathway Diagram
 Ribosome Biogenesis In Eukaryotes Pathway antibodies  Ribosome Biogenesis In Eukaryotes Pathway Diagram

Diseases associated with anti-GNL3L antibody

 Disease Name  Pubmed Publications
 Neoplasm Metastasis Antibodies  >1 publications with GNL3L and Neoplasm Metastasis
 Breast Neoplasms Antibodies  >1 publications with GNL3L and Breast Neoplasms

Organs/Tissues associated with anti-GNL3L antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >1 publications with GNL3L and Bone
 Kidney Antibodies  >1 publications with GNL3L and Kidney
 Eye Antibodies  >1 publications with GNL3L and Eye
 Muscle Antibodies  >1 publications with GNL3L and Muscle
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