Rab11B Antibody – Rat Monoclonal

The Ras superfamily of small GTP-binding proteins, which includes the Ras (see MIM 190020), Ral (see MIM 179550), Rho (see MIM 165390), Rap (see MIM 179520), and Rab (see MIM 179508) families, is involved in controlling a diverse set of essential cellular functions. The Rab family, including RAB11B, appears to play a critical role in regulating exocytotic and endocytotic pathways (summary by Zhu et al., 1994 [PubMed 7811277]).[supplied by OMIM, Nov 2010]

RAB11B: GTPase that modulates endosomal trafficking. Acts as a major regulator of membrane delivery during cytokinesis. Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 and RAB11FIP4. Belongs to the small GTPase superfamily. Rab family.

Protein type: G protein, monomeric; G protein, monomeric, Rab; G protein

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: phagocytic vesicle membrane; synaptic vesicle; recycling endosome; synaptic vesicle membrane; mitochondrion; recycling endosome membrane; phagocytic vesicle; cell junction

Molecular Function: GTPase activity; protein binding; GDP binding; GTP binding; myosin V binding

Biological Process: receptor recycling; intracellular protein transport; regulated secretory pathway; constitutive secretory pathway; transferrin transport; Rab protein signal transduction; melanosome transport