NCOR1 Antibody – Mouse Monoclonal

This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.[provided by RefSeq, Jun 2010]

N-CoR1: is a protein that regulates the activity of some transcription factors, including nuclear receptors, by promoting histone deacetylation and chromatin condensation, thereby altering the accessibility of various genes to the transcriptional machinery. Is known to play a role genetic programming including that for myogenesis. Is a component of a large corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2. This complex associates with the thyroid and the retinoic acid receptors in the absence of ligand. Interacts with the catalytic domain of HDAC9. Increased expression correlates with the loss of vitamin D responsiveness in aggressive androgen-independent prostate cancer cells. Its gene tends to be overexpressed in multiple-myeloma cell lines.

Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 17p11.2

Cellular Component: nucleoplasm; transcription factor complex; membrane; transcriptional repressor complex; Sin3 complex; spindle microtubule; histone deacetylase complex; cytoplasm; nuclear chromatin; nucleus

Molecular Function: retinoid X receptor binding; protein binding; histone deacetylase regulator activity; sequence-specific DNA binding; histone deacetylase binding; chromatin binding; thyroid hormone receptor binding; transcription corepressor activity; transcription factor activity; nuclear hormone receptor binding

Biological Process: transcription from RNA polymerase II promoter; circadian rhythm; CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation; transcription initiation from RNA polymerase II promoter; negative regulation of JNK cascade; Notch signaling pathway; establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; regulation of multicellular organism growth; cellular lipid metabolic process; chromatin modification; thalamus development; spindle assembly; negative regulation of transcription from RNA polymerase II promoter; positive regulation of histone deacetylation; cholesterol homeostasis; transforming growth factor beta receptor signaling pathway; gene expression; circadian regulation of gene expression; negative regulation of phosphoinositide 3-kinase cascade