SYP Antibody – Mouse Monoclonal

SYP: Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity. Homohexamer or homotetramer. Interacts with SRCIN1. Characteristic of a type of small (30-80 nm) neurosecretory vesicles, including presynaptic vesicles, but also vesicles of various neuroendocrine cells of both neuronal and epithelial phenotype. Belongs to the synaptophysin/synaptobrevin family.

Protein type: Vesicle; Membrane protein, integral; Membrane protein, multi-pass

Cellular Component: neuron projection; protein complex; synaptic vesicle membrane; integral to membrane; terminal button; excitatory synapse; intracellular organelle; integral to synaptic vesicle membrane; presynaptic membrane; synaptic vesicle; membrane; presynaptic active zone; synapse; cytoplasmic vesicle; cell junction

Molecular Function: identical protein binding; protein domain specific binding; protein binding; transporter activity; protein complex binding; cholesterol binding; syntaxin-1 binding; SH2 domain binding

Biological Process: regulation of long-term neuronal synaptic plasticity; synaptic transmission; transport; endocytosis; regulation of short-term neuronal synaptic plasticity; regulation of neuronal synaptic plasticity