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Keratin K17 (KRT17) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS830225

MBS830225 is an antibody targeting KRT17. Also known as Keratin K17 antibody. Host: Mouse. Mouse monoclonal Keratin K17 antibody More details

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Testing Data View PDF
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Product Overview

Product Name
Keratin K17 (KRT17), Monoclonal Antibody
Full Product Name
Keratin K17 antibody
Product Gene Name
anti-KRT17 antibody
Product Synonym Names
Monoclonal Keratin K17; Anti Keratin K17; Keratin K17; Keratin K 17; Keratin K-17; Cytokeratin 17
Clonality
Monoclonal
Isotype
IgG2b
Clone Number
Ks17.E3
Host
Mouse
Form/Format
Supplied in liquid form, contains 0.09% NaN3
Specificity
Human keratin K17
Preparation and Storage
Store at 2-8 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
Molecular Weight
48,106 Da
OMIM
148069
3D Structure
ModBase 3D Structure for Q04695
Cross-Reactivity
Rat
Immunogen
Keratin K17 antibody was raised in mouse using human keratin K17 as the immunogen.

Product Categories/Family for anti-KRT17 antibody

Cell Biology
Applications Tested/Suitable for anti-KRT17 antibody
Immunohistochemistry (IHC), Western Blot (WB)

Other Notes

Small volumes of anti-KRT17 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for KRT17. It may not necessarily be applicable to this product.

NCBI GI #
4557701
NCBI GeneID
3872
NCBI Accession #
NP_000413.1
UniProt Primary Accession #
Q04695
UniProt Secondary Accession #
Q6IP98; Q8N1P6; A5Z1M9; A5Z1N0; A5Z1N1; A5Z1N2; A6NDV6; A6NKQ2
UniProt Related Accession #
Q04695
GenBank Nucleotide #
NM_000422.2
NCBI Official Full Name
keratin, type I cytoskeletal 17
NCBI Official Synonym Full Names
keratin 17, type I
NCBI Official Symbol
KRT17
NCBI Official Synonym Symbols
PC; K17; PC2; PCHC1
UniProt Protein Name
Keratin, type I cytoskeletal 17
UniProt Synonym Protein Names
39.1; Cytokeratin-17; CK-17; Keratin-17; K17
Protein Family
Keratin
UniProt Gene Name
KRT17
UniProt Synonym Gene Names
CK-17; K17
UniProt Entry Name
K1C17_HUMAN
NCBI Protein Information
keratin, type I cytoskeletal 17

NCBI Summary for KRT17

This gene encodes the type I intermediate filament chain keratin 17, expressed in nail bed, hair follicle, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. [provided by RefSeq, Aug 2008]

UniProt Comments for KRT17

K17: a type I cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. There are two types of cytoskeletal and microfibrillar keratin: type I (acidic; 40-55 kDa) [K9 to K20] and type II (neutral to basic; 56-70 kDa) [K1 to K8]. Both a basic and an acidic keratin are required for filament assembly. Generally associates with K6.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 17q21.2

Cellular Component: cytoplasm; intermediate filament

Molecular Function: MHC class II receptor activity; protein binding; structural constituent of cytoskeleton; MHC class II protein binding

Biological Process: positive regulation of hair follicle development; epidermis development; hair follicle morphogenesis; positive regulation of translation; keratinization; intermediate filament organization; signal transduction; positive regulation of cell growth

Disease: Steatocystoma Multiplex; Pachyonychia Congenita 2
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Research Articles on KRT17

1. These findings functionally integrate K17, hnRNP K, and gene expression along with RSK and CXCR3 signaling in a keratinocyte-autonomous axis and provide a potential basis for their implication in tumorigenesis

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-KRT17 antibody

 Products by Pathway  Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 Glucocorticoid Receptor Regulatory Network Pathway antibodies  Glucocorticoid Receptor Regulatory Network Pathway Diagram

Diseases associated with anti-KRT17 antibody

 Disease Name  Pubmed Publications
 Pachyonychia Congenita Antibodies  >25 publications with KRT17 and Pachyonychia Congenita
 Carcinoma, Squamous Cell Antibodies  >9 publications with KRT17 and Carcinoma, Squamous Cell
 Adenocarcinoma Antibodies  >7 publications with KRT17 and Adenocarcinoma
 Breast Neoplasms Antibodies  >6 publications with KRT17 and Breast Neoplasms
 Pain Antibodies  >4 publications with KRT17 and Pain
 Esophageal Squamous Cell Carcinoma Antibodies  >3 publications with KRT17 and Esophageal Squamous Cell Carcinoma
 Cell Transformation, Neoplastic Antibodies  >2 publications with KRT17 and Cell Transformation, Neoplastic
 Steatocystoma Multiplex Antibodies  >2 publications with KRT17 and Steatocystoma Multiplex
 Uterine Cervical Neoplasms Antibodies  >2 publications with KRT17 and Uterine Cervical Neoplasms
 Precancerous Conditions Antibodies  >2 publications with KRT17 and Precancerous Conditions

Organs/Tissues associated with anti-KRT17 antibody

 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >19 publications with KRT17 and Skin
 Mouth Antibodies  >4 publications with KRT17 and Mouth
 Lymph Antibodies  >2 publications with KRT17 and Lymph
 Mammary Gland Antibodies  >2 publications with KRT17 and Mammary Gland
 Lymph Node Antibodies  >2 publications with KRT17 and Lymph Node
 Bone Antibodies  >2 publications with KRT17 and Bone
 Cervix Antibodies  >2 publications with KRT17 and Cervix
 Bladder Antibodies  >1 publications with KRT17 and Bladder
 Prostate Antibodies  >1 publications with KRT17 and Prostate
 Muscle Antibodies  >1 publications with KRT17 and Muscle
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