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GSC Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS830505

MBS830505 is an antibody targeting GSC. Also known as GSC antibody. Host: Mouse. Mouse monoclonal GSC antibody More details

$1615 / 0.1 mL +2 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
GSC, Monoclonal Antibody
Full Product Name
GSC antibody
Product Gene Name
anti-GSC antibody
Product Synonym Names
Monoclonal GSC; Anti-GSC; Goosecoid homeobox; Homeobox protein goosecoid
Clonality
Monoclonal
Isotype
IgG1
Clone Number
1D7
Host
Mouse
Form/Format
Supplied in PBS buffer, pH 7.3, containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purity/Purification
GSC antibody was purified by affinity chromatography.
Concentration
500 ug-1 mg/ml (lot specific)
Preparation and Storage
Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
Molecular Weight
28,150 Da
OMIM
138890
3D Structure
ModBase 3D Structure for P56915
Cross-Reactivity
Human
Immunogen
GSC antibody was raised in mouse using a human recombinant protein fragment corresponding to amino acids 107-257 of human GSC (NP_776248) produced in E Coli as the immunogen.

Product Categories/Family for anti-GSC antibody

Differentiation & Development
Applications Tested/Suitable for anti-GSC antibody
Flow Cytometry (FC/FACS), Immunohistochemistry (IHC), Western Blot (WB)
Application Notes for anti-GSC antibody
FC: 1:100
IHC: 1:50
WB: 1:500-1000

Western Blot (WB) of anti-GSC antibody

Western Blot analysis of HEK293T cell lysates (5 ug) transfected with either recombinant GSC protein (Right) or empty vector (Left) detected with GSC antibody
Mouse Anti-GSC Monoclonal Antibody – Cat# MBS830505

Immunohistochemistry (IHC) of anti-GSC antibody

Immunohistochemical analysis of GSC protein in paraffin embedded Carcinoma of Human kidney tissue using GSC antibody
Mouse Anti-GSC Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS830505

Other Notes

Small volumes of anti-GSC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for GSC. It may not necessarily be applicable to this product.

NCBI GI #
27777663
NCBI GeneID
145258
NCBI Accession #
NP_776248
UniProt Primary Accession #
P56915
UniProt Secondary Accession #
Q86YR1
UniProt Related Accession #
P56915
GenBank Nucleotide #
NM_173849.2
NCBI Official Full Name
homeobox protein goosecoid
NCBI Official Synonym Full Names
goosecoid homeobox
NCBI Official Symbol
GSC
NCBI Official Synonym Symbols
SAMS
UniProt Protein Name
Homeobox protein goosecoid
Protein Family
Homeobox protein
UniProt Gene Name
GSC
UniProt Entry Name
GSC_HUMAN
NCBI Protein Information
homeobox protein goosecoid

NCBI Summary for GSC

This gene encodes a member of the bicoid subfamily of the paired (PRD) homeobox family of proteins. The encoded protein acts as a transcription factor and may be autoregulatory. A similar protein in mice plays a role in craniofacial and rib cage development during embryogenesis. [provided by RefSeq, Jul 2008]
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UniProt Comments for GSC

GSC: Regulates chordin (CHRD). May play a role in spatial programing within discrete embryonic fields or lineage compartments during organogenesis. In concert with NKX3-2, plays a role in defining the structural components of the middle ear; required for the development of the entire tympanic ring. Belongs to the paired homeobox family. Bicoid subfamily.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 14q32.1

Cellular Component: transcription factor complex; nucleus

Molecular Function: sequence-specific DNA binding

Biological Process: neural crest cell fate specification; negative regulation of Wnt receptor signaling pathway; forebrain development; gastrulation; negative regulation of transcription from RNA polymerase II promoter; middle ear morphogenesis; muscle morphogenesis; dorsoventral neural tube patterning; embryonic skeletal morphogenesis

Disease: Short Stature, Auditory Canal Atresia, Mandibular Hypoplasia, And Skeletal Abnormalities
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Research Articles on GSC

1. GSC is also a prognostic factor for poor survival and metastasis of HCC, which suggests its potential as a therapeutic target for metastatic HCC.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-GSC antibody

 Reference Product  PubMed Publications
 SOX2 antibody  >27 publications with GSC and SOX2
 NANOG antibody  >11 publications with GSC and NANOG
 SMAD2 antibody  >9 publications with GSC and SMAD2
 SMAD4 antibody  >6 publications with GSC and SMAD4
 FOXH1 antibody  >5 publications with GSC and FOXH1
 SMAD3 antibody  >3 publications with GSC and SMAD3
 E2F1 antibody  >2 publications with GSC and E2F1
 RB1 antibody  >1 publications with GSC and RB1

Pathways associated with anti-GSC antibody

 Products by Pathway  Pathway Diagram
 Regulation Of Nuclear SMAD2/3 Signaling Pathway antibodies  Regulation Of Nuclear SMAD2/3 Signaling Pathway Diagram
 Regulation Of Retinoblastoma Protein Pathway antibodies  Regulation Of Retinoblastoma Protein Pathway Diagram

Diseases associated with anti-GSC antibody

 Disease Name  Pubmed Publications
 Death Antibodies  >57 publications with GSC and Death
 Craniofacial Abnormalities Antibodies  >28 publications with GSC and Craniofacial Abnormalities
 Embryo Loss Antibodies  >24 publications with GSC and Embryo Loss
 Abnormalities, Multiple Antibodies  >16 publications with GSC and Abnormalities, Multiple
 Neoplasm Metastasis Antibodies  >16 publications with GSC and Neoplasm Metastasis
 Neoplasms, Experimental Antibodies  >14 publications with GSC and Neoplasms, Experimental
 Necrosis Antibodies  >12 publications with GSC and Necrosis
 Inflammation Antibodies  >10 publications with GSC and Inflammation
 Neurobehavioral Manifestations Antibodies  >10 publications with GSC and Neurobehavioral Manifestations
 Cardiovascular Abnormalities Antibodies  >9 publications with GSC and Cardiovascular Abnormalities

Organs/Tissues associated with anti-GSC antibody

 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >104 publications with GSC and Embryonic Tissue
 Bone Antibodies  >89 publications with GSC and Bone
 Connective Tissue Antibodies  >8 publications with GSC and Connective Tissue
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