NCOA3 Antibody – Mouse Monoclonal

The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Several transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein. [provided by RefSeq, Mar 2010]

SRC-3: a histone acetyltransferase and nuclear receptor coactivator. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit. Activity is enhanced by various hormones and TNF. Acetylation by CREBBP may suppress coactivation of target genes by disrupting its association with nuclear receptors. Frequently amplified or overexpressed in breast and ovarian cancers. Five alternatively spliced isoforms have been described.

Protein type: Acetyltransferase; Nuclear receptor co-regulator; Motility/polarity/chemotaxis; EC 2.3.1.48; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 20q12

Cellular Component: nucleoplasm; cytoplasm; nucleus

Molecular Function: protein dimerization activity; ligand-dependent nuclear receptor binding; signal transducer activity; protein binding; histone acetyltransferase activity; androgen receptor binding; ligand-dependent nuclear receptor transcription coactivator activity; transcription coactivator activity; protein N-terminus binding; thyroid hormone receptor binding; chromatin binding; nuclear hormone receptor binding

Biological Process: developmental growth; intracellular receptor-mediated signaling pathway; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; multicellular organism growth; androgen receptor signaling pathway; vagina development; positive regulation of transcription from RNA polymerase II promoter; histone acetylation; positive regulation of keratinocyte differentiation; cellular response to hormone stimulus