ELK3 Antibody – Mouse Monoclonal

This gene encodes a member of the ETS-domain transcription factor family and the ternary complex factor (TCF) subfamily. Proteins in this subfamily regulate transcription when recruited by serum response factor to bind to serum response elements. This protein is activated by signal-induced phosphorylation; studies in rodents suggest that it is a transcriptional inhibitor in the absence of Ras, but activates transcription when Ras is present. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

ELK3: a transcription factor of the ETS-domain transcription factor family and the ternary complex factor (TCF) subfamily. May be a negative regulator of transcription but can activate transcription when co expressed with Ras, Src or Mos. Activated by signal-induced phosphorylation; studies in rodents suggest that it is a transcriptional inhibitor in the absence of Ras, but activates transcription when Ras is present.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 12q23

Cellular Component: nucleoplasm; mitochondrion; intracellular membrane-bound organelle; nucleus

Molecular Function: protein binding; transcription corepressor activity; purine-rich negative regulatory element binding; transcription factor activity

Biological Process: regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter; wound healing; positive regulation of transcription from RNA polymerase II promoter; angiogenesis; signal transduction; negative regulation of transcription, DNA-dependent; cell differentiation