E2F7 Antibody – Rabbit Polyclonal

E2F7: Along with E2F8, inhibitor of E2F-dependent transcription that is important for the control of the E2F1-TP53 apoptotic pathway. Directly represses E2F1 transcription. Binds DNA independently of DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'. Appears to regulate a subset of E2F-dependent genes whose products are required for normal cell cycle progession. Belongs to the E2F/DP family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor; DNA-binding; Cell cycle regulation

Cellular Component: transcription factor complex; intracellular; nucleus

Molecular Function: identical protein binding; protein binding; DNA binding; transcription corepressor activity; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; negative regulation of cell proliferation; DNA damage response, signal transduction by p53 class mediator; transcription, DNA-dependent; regulation of transcription, DNA-dependent; positive regulation of DNA endoreduplication; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; sprouting angiogenesis; cell cycle; response to DNA damage stimulus; negative regulation of cytokinesis; placenta development