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LCMT1 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS832880

MBS832880 is an antibody targeting LCMT1. Also known as LCMT1 antibody. Host: Mouse. Mouse monoclonal LCMT1 antibody More details

$1625 / 0.1 mL +2 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
LCMT1, Monoclonal Antibody
Full Product Name
LCMT1 antibody
Product Gene Name
anti-LCMT1 antibody
Product Synonym Names
Monoclonal LCMT1; Anti-LCMT1; Leucine carboxyl methyltransferase 1; PPMT1; Protein-leucine O methyltransferase; LCMT; Protein phosphatase methyltransferase 1; LCMT1; LCMT 1; LCMT-1
Clonality
Monoclonal
Isotype
IgG2b
Clone Number
4A5
Host
Mouse
Form/Format
Supplied in PBS buffer, pH 7.3, containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purity/Purification
LCMT1 antibody was purified by affinity chromatography.
Concentration
500 ug-1 mg/ml (lot specific)
Preparation and Storage
Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
Molecular Weight
32,172 Da
OMIM
610286
Cross-Reactivity
Human
Immunogen
LCMT1 antibody was raised in mouse using a full length recombinant protein of human LCMT1 (NP_057393) produced in HEK293 cell as the immunogen.

Product Categories/Family for anti-LCMT1 antibody

Proteases; Inhibitors; & Enzymes
Applications Tested/Suitable for anti-LCMT1 antibody
Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB)
Application Notes for anti-LCMT1 antibody
FC: 1:100
IF: 1:100
IHC: 1:150
WB: 1:2000

Flow Cytometry of anti-LCMT1 antibody

Flow Cytometric analysis using LCMT1 antibody
Flow Cytometric analysis of HEK293T cells transfected with either recombinant LCMT1 protein (red) or empty vector (blue) stained using LCMT1 antibody
Mouse Anti-LCMT1 Monoclonal Antibody – Cat# MBS832880

Immunofluorescence of anti-LCMT1 antibody

Immunofluorescent staining using LCMT1 antibody
Immunofluorescent staining of COS7 cells transiently transfected with recombinant LCMT1 protein using LCMT1 antibody
Mouse Anti-LCMT1 Monoclonal Antibody, Immunofluorescence – Cat# MBS832880

Immunohistochemistry of anti-LCMT1 antibody

Immunohistochemical staining using LCMT1 antibody
Immunohistochemical analysis of LCMT1 protein in paraffin embedded Adenocarcinoma of Human colon tissue using LCMT1 antibody
Mouse Anti-LCMT1 Monoclonal Antibody, Immunohistochemistry – Cat# MBS832880

Western Blot of anti-LCMT1 antibody

Western Blot analysis using LCMT1 antibody
Western Blot analysis of HEK293T cell lysates (5 ug) transfected with either recombinant LCMT1 protein (Right) or empty vector (Left) detected with LCMT1 antibody
Mouse Anti-LCMT1 Monoclonal Antibody, Western Blot – Cat# MBS832880

Other Notes

Small volumes of anti-LCMT1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for LCMT1. It may not necessarily be applicable to this product.

NCBI GI #
74048434
NCBI GeneID
51451
NCBI Accession #
NP_057393
UniProt Secondary Accession #
Q53FC5; Q96CI5; Q9H6I9; Q9NTG4; Q9Y378; A6NL89; A8K770
UniProt Related Accession #
Q9UIC8
GenBank Nucleotide #
NM_016309.2
NCBI Official Full Name
leucine carboxyl methyltransferase 1 isoform a
NCBI Official Synonym Full Names
leucine carboxyl methyltransferase 1
NCBI Official Symbol
LCMT1
NCBI Official Synonym Symbols
LCMT; PPMT1; CGI-68
UniProt Protein Name
Leucine carboxyl methyltransferase 1
UniProt Synonym Protein Names
Protein-leucine O-methyltransferase; [Phosphatase 2A protein]-leucine-carboxy methyltransferase 1
Protein Family
Leucine carboxyl methyltransferase
UniProt Gene Name
LCMT1
UniProt Synonym Gene Names
LCMT
UniProt Entry Name
LCMT1_HUMAN
NCBI Protein Information
leucine carboxyl methyltransferase 1

NCBI Summary for LCMT1

LCMT1 catalyzes the methylation of the carboxyl group of the C-terminal leucine residue (leu309) of the catalytic subunit of protein phosphatase-2A (PPP2CA; MIM 176915) (De Baere et al., 1999 [PubMed 10600115]).[supplied by OMIM, Mar 2008]

UniProt Comments for LCMT1

LCMT1: Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues. Belongs to the methyltransferase superfamily. LCMT family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Methyltransferase; Lipid Metabolism - androgen and estrogen; Amino Acid Metabolism - tyrosine; EC 2.1.1.233; Other Amino Acids Metabolism - selenoamino acid; Amino Acid Metabolism - histidine

Chromosomal Location of Human Ortholog: 16p12.1

Cellular Component: cytosol

Molecular Function: protein binding; C-terminal protein carboxyl methyltransferase activity; S-adenosylmethionine-dependent methyltransferase activity

Biological Process: regulation of apoptosis; protein amino acid methylation; C-terminal protein amino acid methylation; protein modification process; negative regulation of protein complex assembly
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Research Articles on LCMT1

1. alterations in the membrane localization of PP2A and Tau following down-regulation of LCMT1 may lead to PP2A and Tau dysfunction in AD.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-LCMT1 antibody

 Reference Product  PubMed Publications
 PPP2CA antibody  >9 publications with LCMT1 and PPP2CA
 PPP2CB antibody  >8 publications with LCMT1 and PPP2CB
 PPP2R4 antibody  >1 publications with LCMT1 and PPP2R4
 PPME1 antibody  >1 publications with LCMT1 and PPME1
 PPP2R2A antibody  >1 publications with LCMT1 and PPP2R2A

Organs/Tissues associated with anti-LCMT1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >4 publications with LCMT1 and Brain
 Vascular Antibodies  >1 publications with LCMT1 and Vascular
 Embryonic Tissue Antibodies  >1 publications with LCMT1 and Embryonic Tissue
 Pancreas Antibodies  >1 publications with LCMT1 and Pancreas
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