ZNF326 Antibody – Rabbit Polyclonal

ZNF326: Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. May play a role in neuronal differentiation and is able to bind DNA and activate expression in vitro. Belongs to the AKAP95 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor; RNA-binding

Chromosomal Location of Human Ortholog: 1p22.2

Cellular Component: nucleoplasm; spliceosome; nuclear matrix; intracellular membrane-bound organelle

Molecular Function: protein binding; DNA binding; zinc ion binding

Biological Process: transcription, DNA-dependent; RNA splicing; positive regulation of transcription, DNA-dependent; mRNA processing; regulation of RNA elongation