PDE2A Antibody – Mouse Monoclonal

PDE2A: Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Belongs to the cyclic nucleotide phosphodiesterase family. PDE2 subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Nucleotide Metabolism - purine; EC 3.1.4.17; Mitochondrial; Phosphodiesterase

Chromosomal Location of Human Ortholog: 11q13.4

Cellular Component: presynaptic membrane; Golgi apparatus; endoplasmic reticulum; mitochondrial matrix; axon; perinuclear region of cytoplasm; cytoplasm; dendrite; plasma membrane; cytosol; nucleus

Molecular Function: protein binding; protein homodimerization activity; TPR domain binding; metal ion binding; calcium channel activity; cGMP-stimulated cyclic-nucleotide phosphodiesterase activity; cyclic-nucleotide phosphodiesterase activity; cGMP binding; drug binding; cAMP binding

Biological Process: monocyte differentiation; cGMP-mediated signaling; metabolic process; cAMP catabolic process; negative regulation of transcription from RNA polymerase II promoter; positive regulation of vascular permeability; negative regulation of cAMP biosynthetic process; cAMP-mediated signaling; negative regulation of protein import into nucleus, translocation; negative regulation of vascular permeability; regulation of cGMP metabolic process; cGMP catabolic process; blood coagulation; protein targeting to mitochondrion; positive regulation of inflammatory response