SERPINE2 Antibody – Mouse Monoclonal

This gene encodes a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. Thrombin, urokinase, plasmin and trypsin are among the proteases that this family member can inhibit. This gene is a susceptibility gene for chronic obstructive pulmonary disease and for emphysema. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

SERPINE2: Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin. Belongs to the serpin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Inhibitor; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 2q36.1

Cellular Component: extracellular matrix; extracellular space; extrinsic to external side of plasma membrane; extracellular region; neuromuscular junction; cytosol; vesicle

Molecular Function: heparin binding; serine-type endopeptidase inhibitor activity; protein binding; glycosaminoglycan binding; receptor binding

Biological Process: negative regulation of proteolysis; regulation of synaptic transmission, glutamatergic; secretory granule organization and biogenesis; cerebellar granular layer morphogenesis; negative regulation of blood coagulation; mating plug formation; detection of mechanical stimulus involved in sensory perception; regulation of cell migration; negative regulation of cell proliferation; negative regulation of smoothened signaling pathway; negative regulation of cell growth; negative regulation of protein catabolic process; blood coagulation; regulation of timing of cell differentiation; positive regulation of astrocyte differentiation; secretion by cell; negative regulation of phosphoinositide 3-kinase cascade