PTPRE Antibody – Mouse Monoclonal

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Two alternatively spliced transcript variants of this gene have been reported, one of which encodes a receptor-type PTP that possesses a short extracellular domain, a single transmembrane region, and two tandem intracytoplasmic catalytic domains; Another one encodes a PTP that contains a distinct hydrophilic N-terminus, and thus represents a nonreceptor-type isoform of this PTP. Studies of the similar gene in mice suggested the regulatory roles of this PTP in RAS related signal transduction pathways, cytokines induced SATA signaling, as well as the activation of voltage-gated K+ channels. [provided by RefSeq, Jul 2008]

PTPRE: a cytoplasmic and transmembrane receptor protein tyrosine phosphatase that regulates IL-10 and TNFA biosynthesis, myelination and cell-matrix adhesion, overexpression reduces tumor development

Protein type: EC 3.1.3.48; Receptor protein phosphatase, tyrosine; Motility/polarity/chemotaxis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 10q26

Cellular Component: cytoplasm; plasma membrane; integral to membrane; nucleus

Molecular Function: protein binding; protein homodimerization activity; transmembrane receptor protein tyrosine phosphatase activity

Biological Process: negative regulation of insulin receptor signaling pathway; protein amino acid dephosphorylation; transmembrane receptor protein tyrosine phosphatase signaling pathway; regulation of mast cell activation