PPP5C Antibody – Mouse Monoclonal

This gene encodes a serine/threonine phosphatase which is a member of the protein phosphatase catalytic subunit family. Proteins in this family participate in pathways regulated by reversible phosphorylation at serine and threonine residues; many of these pathways are involved in the regulation of cell growth and differentiation. The product of this gene has been shown to participate in signaling pathways in response to hormones or cellular stress, and elevated levels of this protein may be associated with breast cancer development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2011]

PPP5C: a Ser/Thr phosphatase. Plays a role in the survival of cells in a low oxygen stress by suppressing a hypoxia-induced ASK-1/MKK4/JNK signaling cascade that promotes apoptosis. Has been reported to interact with DNA-PK, dephosphorylating it at two functional sites. May play a role in the regulation of RNA biogenesis and/or mitosis.

Protein type: Protein phosphatase, Ser/Thr (non-receptor); EC 3.1.3.16

Chromosomal Location of Human Ortholog: 19q13.3

Cellular Component: nucleoplasm; neuron projection; cell soma; intracellular membrane-bound organelle; membrane; cytoplasm; cytosol; nucleus

Molecular Function: identical protein binding; signal transducer activity; protein binding; RNA binding; metal ion binding; protein serine/threonine phosphatase activity; lipid binding; phosphoprotein phosphatase activity

Biological Process: mitosis; positive regulation of I-kappaB kinase/NF-kappaB cascade; transcription, DNA-dependent; protein heterooligomerization; response to morphine; DNA repair; protein amino acid dephosphorylation; signal transduction