RPN1 Antibody – Mouse Monoclonal

This gene encodes a type I integral membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein forms part of the regulatory subunit of the 26S proteasome and may mediate binding of ubiquitin-like domains to this proteasome. [provided by RefSeq, Jul 2008]

RPN1: Essential subunit of N-oligosaccharyl transferase enzyme which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Belongs to the OST1 family.

Protein type: EC 2.4.99.18; Glycan Metabolism - N-glycan biosynthesis; Transferase; Membrane protein, integral

Chromosomal Location of Human Ortholog: 3q21.3

Cellular Component: endoplasmic reticulum membrane; rough endoplasmic reticulum; membrane; oligosaccharyl transferase complex; melanosome; integral to membrane

Molecular Function: protein binding; dolichyl-diphosphooligosaccharide-protein glycotransferase activity

Biological Process: SRP-dependent cotranslational protein targeting to membrane; cellular protein metabolic process; translation; protein modification process; gene expression; protein amino acid N-linked glycosylation via asparagine; post-translational protein modification