RUNX3 Antibody – Rabbit Polyclonal

AML2: CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, lck, IL-3 and GM-CSF promoters. Heterodimer of an alpha and a beta subunit. The alpha subunit binds DNA as a monomer and through the Runt domain. DNA- binding is increased by heterodimerization. Interacts with TLE1 and SUV39H1. The tyrosine phosphorylated form (via runt domain) interacts with SRC (via protein kinase domain). Interacts with FYN and LCK. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Transcription factor

Cellular Component: Golgi apparatus; intracellular membrane-bound organelle; nuclear chromatin; cytoplasm; nucleolus; nucleus

Molecular Function: protein binding; DNA binding; transcription factor activity; ATP binding

Biological Process: axon guidance; ossification; hair follicle morphogenesis; transcription, DNA-dependent; cell maturation; negative regulation of transcription from RNA polymerase II promoter; mRNA transcription from RNA polymerase II promoter; protein amino acid phosphorylation; negative regulation of cell cycle; regulation of transcription, DNA-dependent; regulation of cell differentiation; interferon-gamma production; chondrocyte differentiation; hemopoiesis; neurite development; negative regulation of epithelial cell proliferation