PDE6G Antibody – Mouse Monoclonal

This gene encodes the gamma subunit of cyclic GMP-phosphodiesterase, which is composed of alpha- and beta- catalytic subunits and two identical, inhibitory gamma subunits. This gene is expressed in rod photoreceptors and functions in the phototransduction signaling cascade. It is also expressed in a variety of other tissues, and has been shown to regulate the c-Src protein kinase and G-protein-coupled receptor kinase 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2009]

PDE6G: inhibitory gamma subunit of the retinal photoreceptor type 6 cGMP phosphodiesterase (PDE-gamma). Phosphorylated by GRK2. Regulates EGFR dependent stimulation of ERK1/2. Forms a cellular complex with src. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones. Participates in processes of transmission and amplification of the visual signal.

Protein type: EC 3.1.4.35; Phosphodiesterase; Nucleotide Metabolism - purine

Chromosomal Location of Human Ortholog: 17q25

Cellular Component: plasma membrane

Molecular Function: enzyme inhibitor activity; 3',5'-cyclic-GMP phosphodiesterase activity; protein binding; spectrin binding; cGMP binding

Biological Process: rhodopsin mediated signaling; phototransduction, visible light; regulation of rhodopsin mediated signaling; visual perception; metabolic process; activation of MAPK activity; positive regulation of epidermal growth factor receptor signaling pathway; positive regulation of G-protein coupled receptor protein signaling pathway; negative regulation of catalytic activity

Disease: Retinitis Pigmentosa 57; Retinitis Pigmentosa