Brutons Tyrosine Kinase (BTK) Antibody – Mouse Monoclonal

Btk: a tyrosine kinase of the Tec family. Plays a crucial role in B-cell ontogeny. Defects cause X-linked agammaglobulinemia, an immunodeficiency characterized by failure to produce mature B lymphocyte cells and associated with a failure of Ig heavy chain rearrangement. Truncated splice forms found in childhood leukemias may underlie radiation resistance of tumors through inhibition of apoptosis.

Protein type: Kinase, protein; Protein kinase, tyrosine (non-receptor); Protein kinase, TK; EC 2.7.10.2; TK group; Tec family

Cellular Component: extrinsic to internal side of plasma membrane; mast cell granule; intracellular membrane-bound organelle; membrane; perinuclear region of cytoplasm; cytoplasm; plasma membrane; cytoplasmic vesicle; intracellular; nucleus; cytosol; lipid raft

Molecular Function: transferase activity; identical protein binding; protein binding; phosphatidylinositol-3,4,5-triphosphate binding; metal ion binding; protein-tyrosine kinase activity; transferase activity, transferring phosphorus-containing groups; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; kinase activity; lipid binding; ATP binding; protein kinase activity

Biological Process: I-kappaB kinase/NF-kappaB cascade; adaptive immune response; peptidyl-tyrosine phosphorylation; transcription, DNA-dependent; immune system process; apoptosis; protein amino acid autophosphorylation; cell maturation; protein amino acid phosphorylation; regulation of cell proliferation; response to organic substance; B cell receptor signaling pathway; histamine secretion by mast cell; regulation of transcription, DNA-dependent; innate immune response; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway