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TRIM2 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS834852

MBS834852 is an antibody targeting TRIM2. Also known as TRIM2 antibody. Host: Mouse. Mouse monoclonal TRIM2 antibody More details

$1615 / 0.1 mL +2 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
TRIM2, Monoclonal Antibody
Full Product Name
TRIM2 antibody
Product Gene Name
anti-TRIM2 antibody
Product Synonym Names
Monoclonal TRIM2; Anti-TRIM2; Tripartite motif containing 2; KIAA0517; RNF86; Tripartite motif-containing 2; RING finger protein 86; Tripartite motif protein 2; TRIM2; TRIM 2; TRIM-2
Clonality
Monoclonal
Isotype
IgG1
Clone Number
2B10
Host
Mouse
Form/Format
Supplied in PBS buffer, pH 7.3, containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purity/Purification
TRIM2 antibody was purified by affinity chromatography.
Concentration
500 ug-1 mg/ml (lot specific)
Preparation and Storage
Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
Molecular Weight
54,339 Da
OMIM
608048
3D Structure
ModBase 3D Structure for Q149N8
Cross-Reactivity
Human
Immunogen
TRIM2 antibody was raised in mouse using a human recombinant protein fragment corresponding to amino acids 1-100 and 1500-1600 of human SHPRH (NP_775105) produced in HEK293T cells, as the immunogen.

Product Categories/Family for anti-TRIM2 antibody

Cell Biology
Applications Tested/Suitable for anti-TRIM2 antibody
Flow Cytometry (FC/FACS), Western Blot (WB)
Application Notes for anti-TRIM2 antibody
FC: 1:100
WB: 1:1000-2000

Flow Cytometry (FC/FACS) of anti-TRIM2 antibody

Flow Cytometric analysis of HEK293T cells transfected with either recombinant TRIM2 protein (red) or empty vector (blue) stained using TRIM2 antibody
Mouse Anti-TRIM2 Monoclonal Antibody – Cat# MBS834852

Western Blot (WB) of anti-TRIM2 antibody

Western Blot analysis of HEK293T cell lysates (5 ug) transfected with either recombinant TRIM2 protein (Right) or empty vector (Left) detected with TRIM2 antibody
Mouse Anti-TRIM2 Monoclonal Antibody, Western Blot (WB) – Cat# MBS834852

Other Notes

Small volumes of anti-TRIM2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TRIM2. It may not necessarily be applicable to this product.

NCBI GI #
27436873
NCBI GeneID
257218
NCBI Accession #
NP_775105
UniProt Primary Accession #
Q149N8
UniProt Secondary Accession #
Q149N9; Q5VV79; Q68DS5; Q7Z5J5; Q8IVE8; Q8IWQ9; Q8N1S8; Q8NBR7
UniProt Related Accession #
Q149N8
GenBank Nucleotide #
NM_173082.3
NCBI Official Full Name
E3 ubiquitin-protein ligase SHPRH isoform b
NCBI Official Synonym Full Names
SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase
NCBI Official Symbol
SHPRH
NCBI Official Synonym Symbols
bA545I5.2
UniProt Protein Name
E3 ubiquitin-protein ligase SHPRH
UniProt Synonym Protein Names
SNF2, histone-linker, PHD and RING finger domain-containing helicase
Protein Family
Tripartite motif-containing protein
UniProt Gene Name
SHPRH
UniProt Synonym Gene Names
KIAA2023
UniProt Entry Name
SHPRH_HUMAN
NCBI Protein Information
E3 ubiquitin-protein ligase SHPRH

NCBI Summary for TRIM2

SHPRH is a ubiquitously expressed protein that contains motifs characteristics of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 (Unk et al., 2006 [PubMed 17108083]).[supplied by OMIM, Mar 2008]

UniProt Comments for TRIM2

SHPRH: E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly-ubiquitin chains linked through 'Lys-63'. Belongs to the SNF2/RAD54 helicase family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Ubiquitin ligase; EC 3.6.1.-; EC 6.3.2.-; EC 6.3.2.19; Helicase; EC 3.6.4.-; Ubiquitin conjugating system; Ligase

Chromosomal Location of Human Ortholog: 6q24.3

Cellular Component: nucleosome; nucleus

Molecular Function: DNA binding; zinc ion binding; ubiquitin-protein ligase activity; helicase activity; ATP binding; ligase activity

Biological Process: nucleosome assembly; protein polyubiquitination; DNA repair
Show more

Research Articles on TRIM2

1. HLTF and SHPRH suppress mutagenesis in a damage-specific manner, preventing mutations induced by UV rays and methyl methanesulfonate.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-TRIM2 antibody

 Disease Name  Pubmed Publications
 Anemia Antibodies  >1 publications with TRIM2 and Anemia
 Neoplasm Metastasis Antibodies  >1 publications with TRIM2 and Neoplasm Metastasis
 Lung Diseases Antibodies  >1 publications with TRIM2 and Lung Diseases
 Chromosome Aberrations Antibodies  >1 publications with TRIM2 and Chromosome Aberrations
 Lung Neoplasms Antibodies  >1 publications with TRIM2 and Lung Neoplasms

Organs/Tissues associated with anti-TRIM2 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1 publications with TRIM2 and Blood
 Lung Antibodies  >1 publications with TRIM2 and Lung
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