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ZFP36 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS834930

MBS834930 is an antibody targeting ZFP36. Also known as ZFP36 antibody. Host: Mouse. Mouse monoclonal ZFP36 antibody More details

$1615 / 0.1 mL +2 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
ZFP36, Monoclonal Antibody
Full Product Name
ZFP36 antibody
Product Gene Name
anti-ZFP36 antibody
Product Synonym Names
Monoclonal ZFP36; Anti-ZFP36; Zinc finger protein 36 C3H type homolog; TTP; G0S24; RNF162A; TIS11; NUP475; Growth factor-inducible nuclear protein NUP475; Zinc finger protein 36 homolog; ZFP36; ZFP 36; ZFP-36
Clonality
Monoclonal
Isotype
IgG1
Clone Number
1H6
Host
Mouse
Form/Format
Supplied in PBS buffer, pH 7.3, containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purity/Purification
ZFP36 antibody was purified by affinity chromatography.
Concentration
500 ug-1 mg/ml (lot specific)
Preparation and Storage
Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
Molecular Weight
80,380 Da
OMIM
603896
3D Structure
ModBase 3D Structure for Q13144
Cross-Reactivity
Human
Immunogen
ZFP36 antibody was raised in mouse using a full length recombinant protein of human ZFP36 (NP_003898) produced in HEK293T cells, as the immunogen.

Product Categories/Family for anti-ZFP36 antibody

Cell Biology
Applications Tested/Suitable for anti-ZFP36 antibody
Flow Cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB)
Application Notes for anti-ZFP36 antibody
FC: 1:100
IF: 1:100
WB: 1:2000

Western Blot (WB) of anti-ZFP36 antibody

Western Blot analysis of HEK293T cell lysates (5 ug) transfected with either recombinant ZFP36 protein (Right) or empty vector (Left) detected with ZFP36 antibody
Mouse Anti-ZFP36 Monoclonal Antibody – Cat# MBS834930

Immunofluorescence (IF) of anti-ZFP36 antibody

Immunofluorescent staining of COS7 cells transiently transfected with recombinant ZFP36 protein using ZFP36 antibody
Mouse Anti-ZFP36 Monoclonal Antibody, Immunofluorescence (IF) – Cat# MBS834930

Other Notes

Small volumes of anti-ZFP36 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ZFP36. It may not necessarily be applicable to this product.

NCBI GI #
83267879
NCBI GeneID
8893
NCBI Accession #
NP_003898
UniProt Primary Accession #
Q13144
UniProt Secondary Accession #
Q541Z1; Q96D04
UniProt Related Accession #
Q13144
GenBank Nucleotide #
NM_003907.2
NCBI Official Full Name
translation initiation factor eIF-2B subunit epsilon
NCBI Official Synonym Full Names
eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa
NCBI Official Symbol
EIF2B5
NCBI Official Synonym Symbols
CLE; CACH; LVWM; EIF-2B; EIF2Bepsilon
UniProt Protein Name
Translation initiation factor eIF-2B subunit epsilon
UniProt Synonym Protein Names
eIF-2B GDP-GTP exchange factor subunit epsilon
Protein Family
mRNA decay activator protein
UniProt Gene Name
EIF2B5
UniProt Synonym Gene Names
EIF2BE
UniProt Entry Name
EI2BE_HUMAN
NCBI Protein Information
translation initiation factor eIF-2B subunit epsilon

NCBI Summary for ZFP36

This gene encodes one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Mutations in this gene and the genes encoding other EIF2B subunits have been associated with leukoencephalopathy with vanishing white matter. [provided by RefSeq, Nov 2009]
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UniProt Comments for ZFP36

eIF2B-epsilon: eukaryotic translation initiation factor 2B, subunit 5. A translational regulatory protein that functions in the early steps of protein synthesis by catalyzing the exchange of eukaryotic initiation factor 2-bound GDP for GTP. Mutation in EIF2B5 causes childhood ataxia with central nervous system hypomyelination/ vanishing white matter leukodystrophy.

Protein type: Translation; Translation initiation

Chromosomal Location of Human Ortholog: 3q27.1

Cellular Component: eukaryotic translation initiation factor 2B complex; cytoplasm; cytosol; nucleus

Molecular Function: protein binding; translation initiation factor binding; translation initiation factor activity; guanyl-nucleotide exchange factor activity

Biological Process: myelination; response to peptide hormone stimulus; translation; astrocyte development; positive regulation of translational initiation; cellular protein metabolic process; astrocyte differentiation; ovarian follicle development; response to heat; response to glucose stimulus; translational initiation; gene expression; negative regulation of translation initiation in response to stress; oligodendrocyte development; positive regulation of GTPase activity

Disease: Leukoencephalopathy With Vanishing White Matter
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Research Articles on ZFP36

1. Missense mutations in EIF2B5 are associated with multiple sclerosis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ZFP36 antibody

 Reference Product  PubMed Publications
 EIF2B2 antibody  >37 publications with ZFP36 and EIF2B2
 EIF2B1 antibody  >36 publications with ZFP36 and EIF2B1
 EIF2B4 antibody  >7 publications with ZFP36 and EIF2B4
 EIF2B3 antibody  >7 publications with ZFP36 and EIF2B3

Pathways associated with anti-ZFP36 antibody

 Products by Pathway  Pathway Diagram
 Cap-dependent Translation Initiation Pathway antibodies  Cap-dependent Translation Initiation Pathway Diagram
 Eukaryotic Translation Initiation Pathway antibodies  Eukaryotic Translation Initiation Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 MicroRNAs In Cardiomyocyte Hypertrophy Pathway antibodies  MicroRNAs In Cardiomyocyte Hypertrophy Pathway Diagram
 RNA Transport Pathway antibodies  RNA Transport Pathway Diagram
 RNA Transport Pathway antibodies  RNA Transport Pathway Diagram
 Recycling Of EIF2:GDP Pathway antibodies  Recycling Of EIF2:GDP Pathway Diagram
 Translation Pathway antibodies  Translation Pathway Diagram
 Translation Factors Pathway antibodies  Translation Factors Pathway Diagram

Diseases associated with anti-ZFP36 antibody

 Disease Name  Pubmed Publications
 Neurodegenerative Diseases Antibodies  >12 publications with ZFP36 and Neurodegenerative Diseases
 Neurologic Manifestations Antibodies  >12 publications with ZFP36 and Neurologic Manifestations
 Seizures Antibodies  >3 publications with ZFP36 and Seizures
 Cognition Disorders Antibodies  >2 publications with ZFP36 and Cognition Disorders
 Vascular Diseases Antibodies  >2 publications with ZFP36 and Vascular Diseases
 Inflammation Antibodies  >2 publications with ZFP36 and Inflammation
 Memory Disorders Antibodies  >1 publications with ZFP36 and Memory Disorders
 Carcinoma Antibodies  >1 publications with ZFP36 and Carcinoma
 Neurobehavioral Manifestations Antibodies  >1 publications with ZFP36 and Neurobehavioral Manifestations
 Neoplasms, Experimental Antibodies  >1 publications with ZFP36 and Neoplasms, Experimental

Organs/Tissues associated with anti-ZFP36 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >31 publications with ZFP36 and Brain
 Nerve Antibodies  >9 publications with ZFP36 and Nerve
 Blood Antibodies  >3 publications with ZFP36 and Blood
 Vascular Antibodies  >2 publications with ZFP36 and Vascular
 Muscle Antibodies  >1 publications with ZFP36 and Muscle
 Lung Antibodies  >1 publications with ZFP36 and Lung
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