Rabbit Anti-DOK3 Polyclonal Antibody – Cat# MBS835254

Western blot analysis of 30 ug of whole cell lysate (A: A431) using a 10 % SDS PAGE gel and Docking protein 3 antibody at a dilution of 1:1000

Docking 3 (DOK3) Antibody – Rabbit Polyclonal

Name: DOK3 Antibody; Polyclonal; Rabbit; MyBioSource
Brand: MyBioSource
SKU: MBS835254
Price: 1575 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS835254

MBS835254 is an antibody targeting DOK3. Also known as Docking protein 3 antibody. Host: Rabbit. Affinity purified Rabbit polyclonal Docking protein 3 antibody More details

$1575 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Docking 3 (DOK3), Polyclonal Antibody

Full Product Name

Docking protein 3 antibody

Product Gene Name

anti-DOK3 antibody

Product Synonym Names

Polyclonal Docking protein 3; Anti-Docking protein 3; Docking protein -3; downstream of tyrosine kinase 3; DOK3; FLJ39939; Docking protein 3; DOKL; Dok-like protein; docking protein 3; FLJ22570

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Form/Format

Supplied as a concentrated soloution containing 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH 7.0). 0.01% Thimerosal was added as a preservative.

Purity/Purification

Docking protein 3 antibody was purified by antigen-affinity chromatography

Concentration

1 mg/ml (lot specific)

Preparation and Storage

Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

Molecular Weight

53 kDa

OMIM

611435

3D Structure

ModBase 3D Structure for Q7L591

Cross-Reactivity

Human

Immunogen

Docking protein 3 antibody was raised in rabbit using a synthetic peptide contain a sequence corresponding to a region within amino acids 434 and 446 of DOK3

Product Categories/Family for anti-DOK3 antibody

Cell Biology; Purified Polyclonal Antibodies

Applications Tested/Suitable for anti-DOK3 antibody

Western Blot (WB)

Application Notes for anti-DOK3 antibody

WB: 1:500-1:3000

Other Notes

Small volumes of anti-DOK3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for DOK3. It may not necessarily be applicable to this product.

NCBI GI #

221554541

NCBI GeneID

79930

NCBI Accession #

NP_001138348.1

UniProt Primary Accession #

Q7L591

UniProt Secondary Accession #

Q8N864; Q9BQB3; Q9H666; E9PAT0; H7BXS0

UniProt Related Accession #

Q7L591

GenBank Nucleotide #

NM_001144876.1

NCBI Official Full Name

docking protein 3 isoform 3

NCBI Official Synonym Full Names

docking protein 3

NCBI Official Symbol

DOK3

NCBI Official Synonym Symbols

DOKL

UniProt Protein Name

Docking protein 3

UniProt Synonym Protein Names

Downstream of tyrosine kinase 3

Protein Family

Docking protein

UniProt Gene Name

DOK3

UniProt Entry Name

DOK3_HUMAN

NCBI Protein Information

docking protein 3

UniProt Comments for DOK3

DOK3: docking proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with SHIP. May modulate Abl function. Upon tyrosine phosphorylation, Dok3 interacts with CSK and SHIP via their SH2 domains. Both pY381 and pY398 are required for interaction with SHIP. Only pY381 is required for interaction with CSK. Binds ABL through the PTB domain and in a kinase-dependent manner. On IL2 stimulation, phosphorylated on C-terminal tyrosine residues possibly by Src kinases. Does not interact with RasGAP. Four isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 5q35.3

Cellular Component: cytoplasm; plasma membrane

Molecular Function: protein binding; insulin receptor binding

Biological Process: Ras protein signal transduction

Research Articles on DOK3

1. The Dok-3/Grb2 protein signal module attenuates Lyn kinase-dependent activation of Syk kinase in B cell antigen receptor microclusters

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-DOK3 antibody

Reference Product	PubMed Publications
SRC antibody	>9 publications with DOK3 and SRC
GRB2 antibody	>7 publications with DOK3 and GRB2
LYN antibody	>2 publications with DOK3 and LYN
CSK antibody	>2 publications with DOK3 and CSK

Pathways associated with anti-DOK3 antibody

Products by Pathway	Pathway Diagram
B Cell Receptor Signaling Pathway antibodies	B Cell Receptor Signaling Pathway Diagram

Diseases associated with anti-DOK3 antibody

Disease Name	Pubmed Publications
Fibrosis Antibodies	>2 publications with DOK3 and Fibrosis
Inflammation Antibodies	>2 publications with DOK3 and Inflammation
Adenocarcinoma Antibodies	>1 publications with DOK3 and Adenocarcinoma
Respiratory Tract Infections Antibodies	>1 publications with DOK3 and Respiratory Tract Infections
Hyperplasia Antibodies	>1 publications with DOK3 and Hyperplasia
Necrosis Antibodies	>1 publications with DOK3 and Necrosis
Lung Neoplasms Antibodies	>1 publications with DOK3 and Lung Neoplasms

Organs/Tissues associated with anti-DOK3 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>11 publications with DOK3 and Blood
Lung Antibodies	>3 publications with DOK3 and Lung
Bone Marrow Antibodies	>2 publications with DOK3 and Bone Marrow
Heart Antibodies	>1 publications with DOK3 and Heart
Thymus Antibodies	>1 publications with DOK3 and Thymus
Kidney Antibodies	>1 publications with DOK3 and Kidney
Lymph Node Antibodies	>1 publications with DOK3 and Lymph Node
Spleen Antibodies	>1 publications with DOK3 and Spleen