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Glycine Receptor Alpha 2 (GLRA2) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS835359

MBS835359 is an antibody targeting GLRA2. Also known as Glycine Receptor alpha 2 antibody. Host: Rabbit. Affinity purified Rabbit polyclonal Glycine Receptor alpha 2 antibody More details

$1575 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Glycine Receptor alpha 2 (GLRA2), Polyclonal Antibody
Full Product Name
Glycine Receptor alpha 2 antibody
Product Gene Name
anti-GLRA2 antibody
Product Synonym Names
Polyclonal Glycine Receptor alpha 2; Anti-Glycine Receptor alpha 2; Glycine Receptor alpha 2; GLR; glycine receptor subunit alpha-2; Glycine Receptor alpha -2; glycine receptor alpha-2 polypeptide; GLRA2; glycine receptor alpha 2 subunit
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Form/Format
Supplied as a concentrated soloution containing 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH 7.0). 0.01% Thimerosal was added as a preservative.
Purity/Purification
Glycine Receptor alpha 2 antibody was purified by antigen-affinity chromatography
Concentration
1 mg/ml (lot specific)
Preparation and Storage
Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
Molecular Weight
52 kDa
OMIM
305990
3D Structure
ModBase 3D Structure for P23416
Cross-Reactivity
Human
Immunogen
Glycine Receptor alpha 2 antibody was raised in rabbit using a recombinant fragment corresponding to a region within amino acids 1 and 216 of Glycine Receptor alpha 2

Product Categories/Family for anti-GLRA2 antibody

Signal Transduction; Purified Polyclonal Antibodies
Applications Tested/Suitable for anti-GLRA2 antibody
Immunofluorescence (IF), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Paraffin, Western Blot (WB)
Application Notes for anti-GLRA2 antibody
IF:1:100-1:500
ICC:1:100-1:500
IHC-P: 1:100-1:500
WB: 1:1000-1:10000

Immunohistochemistry (IHC) of anti-GLRA2 antibody

Immunohistochemical staining of paraffin-embedded Breast ca using Glycine Receptor alpha 2 antibody at a dilution of 1:750
Rabbit Anti-GLRA2 Polyclonal Antibody – Cat# MBS835359

Western Blot (WB) of anti-GLRA2 antibody

Western blot analysis of 30 ug of whole cell lysate (A: 293T; B: A431; C: HepG2) using a 10 % SDS PAGE gel and Glycine Receptor alpha 2 antibody at a dilution of 1:5000
Rabbit Anti-GLRA2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS835359

Other Notes

Small volumes of anti-GLRA2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for GLRA2. It may not necessarily be applicable to this product.

NCBI GI #
1684900
NCBI GeneID
2742
NCBI Accession #
AAB38272.1
UniProt Primary Accession #
P23416
UniProt Secondary Accession #
Q53YX7; Q6ICQ0; Q99862; A8K0J6; B2R6I8; B7Z4F5; J3KQ59
UniProt Related Accession #
P23416
NCBI Official Full Name
glycine receptor alpha 2 subunit, partial
NCBI Official Synonym Full Names
glycine receptor, alpha 2
NCBI Official Symbol
GLRA2
NCBI Official Synonym Symbols
GLR
UniProt Protein Name
Glycine receptor subunit alpha-2
Protein Family
Glycine receptor
UniProt Gene Name
GLRA2
UniProt Entry Name
GLRA2_HUMAN
NCBI Protein Information
glycine receptor subunit alpha-2

NCBI Summary for GLRA2

The glycine receptor consists of two subunits, alpha and beta, and acts as a pentamer. The protein encoded by this gene is an alpha subunit and can bind strychnine. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010]

UniProt Comments for GLRA2

GLRA2: The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing). Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA2 sub- subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transporter, ion channel; Membrane protein, multi-pass; Membrane protein, integral; Transporter

Chromosomal Location of Human Ortholog: Xp22.2

Cellular Component: postsynaptic membrane; integral to plasma membrane; plasma membrane; cell junction

Molecular Function: transmitter-gated ion channel activity; extracellular-glycine-gated chloride channel activity; glycine binding

Biological Process: neuropeptide signaling pathway; ion transport; transmembrane transport
Show more

Research Articles on GLRA2

1. investigated neural progenitor cells in respect to their glycine receptor function and subunit expression using electrophysiology, calcium imaging, immunocytochemistry, and quantitative real-time PCR

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-GLRA2 antibody

 Reference Product  PubMed Publications
 GLRB antibody  >9 publications with GLRA2 and GLRB
 GLRA3 antibody  >8 publications with GLRA2 and GLRA3
 GLRA1 antibody  >4 publications with GLRA2 and GLRA1

Pathways associated with anti-GLRA2 antibody

 Products by Pathway  Pathway Diagram
 Ion Channel Transport Pathway antibodies  Ion Channel Transport Pathway Diagram
 Ligand-gated Ion Channel Transport Pathway antibodies  Ligand-gated Ion Channel Transport Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram

Diseases associated with anti-GLRA2 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >5 publications with GLRA2 and Nervous System Diseases
 Inflammation Antibodies  >2 publications with GLRA2 and Inflammation
 Neurobehavioral Manifestations Antibodies  >2 publications with GLRA2 and Neurobehavioral Manifestations
 Brain Diseases Antibodies  >2 publications with GLRA2 and Brain Diseases
 Anemia Antibodies  >1 publications with GLRA2 and Anemia
 Alcohol-Related Disorders Antibodies  >1 publications with GLRA2 and Alcohol-Related Disorders
 Kidney Diseases Antibodies  >1 publications with GLRA2 and Kidney Diseases

Organs/Tissues associated with anti-GLRA2 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >28 publications with GLRA2 and Brain
 Eye Antibodies  >9 publications with GLRA2 and Eye
 Kidney Antibodies  >5 publications with GLRA2 and Kidney
 Embryonic Tissue Antibodies  >2 publications with GLRA2 and Embryonic Tissue
 Ovary Antibodies  >2 publications with GLRA2 and Ovary
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