GRM7 Antibody – Rabbit Polyclonal

L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]

mGluR7: Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. Belongs to the G-protein coupled receptor 3 family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 3; Membrane protein, integral

Chromosomal Location of Human Ortholog: 3p26.1-p25.1

Cellular Component: presynaptic membrane; asymmetric synapse; postsynaptic membrane; integral to plasma membrane; axon; dendrite; plasma membrane; presynaptic active zone; integral to membrane; cell cortex; dendritic shaft; receptor complex

Molecular Function: voltage-gated calcium channel activity; group III metabotropic glutamate receptor activity; glutamate binding; calcium channel regulator activity; calcium ion binding; glutamate receptor activity; PDZ domain binding

Biological Process: regulation of synaptic transmission, glutamatergic; behavioral fear response; negative regulation of glutamate secretion; short-term memory; sensory perception of smell; negative regulation of adenylate cyclase activity; regulation of cyclase activity; transmission of nerve impulse; synaptic transmission; negative regulation of cAMP biosynthetic process; sensory perception of sound; adult behavior; conditioned taste aversion; metabotropic glutamate receptor, adenylate cyclase inhibiting pathway