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Histone Methyltransferase (SMYD3) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS835641

MBS835641 is an antibody targeting SMYD3. Also known as Histone Methyltransferase antibody. Host: Rabbit. Rabbit polyclonal Histone Methyltransferase antibody More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
Histone Methyltransferase (SMYD3), Polyclonal Antibody
Full Product Name
Histone Methyltransferase antibody
Product Gene Name
anti-SMYD3 antibody
Product Synonym Names
Polyclonal Histone Methyltransferase; anti-Histone Methyltransferase; Histone H3-K9 methyltransferase 1; Su(var)3-9 homolog 1; Full=Position-effect variegation 3-9 homolog; Histone-lysine N-methyltransferase; Suppressor of variegation 3-9 homolog 1; H3-K9-HMTase 1; SUV39H1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Form/Format
Supplied in PBS buffer, pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal
Purity/Purification
Histone Methyltransferase antibody was purified by affinity chromatography
Concentration
500 ug/ml (lot specific)
Preparation and Storage
Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
Molecular Weight
42,625 Da
OMIM
608783
Cross-Reactivity
Mouse, Human, Rat
Immunogen
Histone Methyltransferase antibody was raised in Rabbit using synthetic peptide surrounding amino acid 389 of mouse Histone Methyltransferase as the immunogen.

Product Categories/Family for anti-SMYD3 antibody

Proteases; Inhibitors; & Enzymes; Purified Polyclonal Antibodies
Applications Tested/Suitable for anti-SMYD3 antibody
Western Blot (WB)
Application Notes for anti-SMYD3 antibody
WB: 1-4 ug/ml

Western Blot (WB) of anti-SMYD3 antibody

Western blot analysis SUV39H1 with 3T3 cell lysate.
Rabbit Anti-SMYD3 Polyclonal Antibody – Cat# MBS835641

Other Notes

Small volumes of anti-SMYD3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SMYD3. It may not necessarily be applicable to this product.

NCBI GI #
19570495
NCBI GeneID
64754
NCBI Accession #
BAB86333.1
UniProt Secondary Accession #
Q86TL8; Q8N5Z6; Q96AI5; A8K0P0; B1AN38
UniProt Related Accession #
Q9H7B4
NCBI Official Full Name
histone methyltransferase
NCBI Official Synonym Full Names
SET and MYND domain containing 3
NCBI Official Symbol
SMYD3
NCBI Official Synonym Symbols
KMT3E; ZMYND1; ZNFN3A1; bA74P14.1
UniProt Protein Name
Histone-lysine N-methyltransferase SMYD3
UniProt Synonym Protein Names
SET and MYND domain-containing protein 3; Zinc finger MYND domain-containing protein 1
Protein Family
Histone-lysine N-methyltransferase
UniProt Gene Name
SMYD3
UniProt Synonym Gene Names
ZMYND1; ZNFN3A1
UniProt Entry Name
SMYD3_HUMAN
NCBI Protein Information
histone-lysine N-methyltransferase SMYD3

NCBI Summary for SMYD3

This gene encodes a histone methyltransferase which functions in RNA polymerase II complexes by an interaction with a specific RNA helicase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

UniProt Comments for SMYD3

SMYD3: Histone methyltransferase. Specifically methylates 'Lys- 4' of histone H3, inducing di- and tri-methylation, but not monomethylation. Plays an important role in transcriptional activation as a member of an RNA polymerase complex. Binds DNA containing 5'-CCCTCC-3' or 5'-GAGGGG-3' sequences. Belongs to the histone-lysine methyltransferase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Methyltransferase; EC 2.1.1.43; Methyltransferase, protein lysine

Chromosomal Location of Human Ortholog: 1q44

Cellular Component: nucleoplasm; cytoplasm

Molecular Function: metal ion binding; histone-lysine N-methyltransferase activity

Biological Process: nucleosome assembly; establishment of protein localization; establishment and/or maintenance of chromatin architecture; negative regulation of protein kinase activity; myotube cell development; positive regulation of transcription from RNA polymerase II promoter; positive regulation of peptidyl-serine phosphorylation
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Research Articles on SMYD3

1. The expression profiling revealed in the more aggressive diseases (i.e. occurrence of metastases; persistent disease; disease-related death) a significant increase of EZH2 and SMYD3 gene expression.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SMYD3 antibody

 Reference Product  PubMed Publications
 MAP3K2 antibody  >3 publications with SMYD3 and MAP3K2
 MET antibody  >2 publications with SMYD3 and MET
 HELZ antibody  >2 publications with SMYD3 and HELZ
 RASSF1 antibody  >1 publications with SMYD3 and RASSF1
 COPS5 antibody  >1 publications with SMYD3 and COPS5
 MMP9 antibody  >1 publications with SMYD3 and MMP9
 ALOX15 antibody  >1 publications with SMYD3 and ALOX15
 PRDM2 antibody  >1 publications with SMYD3 and PRDM2

Pathways associated with anti-SMYD3 antibody

 Products by Pathway  Pathway Diagram
 Chromatin Modifying Enzymes Pathway antibodies  Chromatin Modifying Enzymes Pathway Diagram
 Chromatin Organization Pathway antibodies  Chromatin Organization Pathway Diagram
 PKMTs Methylate Histone Lysines Pathway antibodies  PKMTs Methylate Histone Lysines Pathway Diagram

Diseases associated with anti-SMYD3 antibody

 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >23 publications with SMYD3 and Carcinoma
 Adenocarcinoma Antibodies  >14 publications with SMYD3 and Adenocarcinoma
 Carcinoma, Hepatocellular Antibodies  >12 publications with SMYD3 and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >10 publications with SMYD3 and Liver Neoplasms
 Breast Neoplasms Antibodies  >9 publications with SMYD3 and Breast Neoplasms
 Skin Diseases Antibodies  >7 publications with SMYD3 and Skin Diseases
 Cell Transformation, Neoplastic Antibodies  >5 publications with SMYD3 and Cell Transformation, Neoplastic
 Neoplasm Metastasis Antibodies  >4 publications with SMYD3 and Neoplasm Metastasis
 Inflammation Antibodies  >3 publications with SMYD3 and Inflammation
 Lung Diseases Antibodies  >2 publications with SMYD3 and Lung Diseases

Organs/Tissues associated with anti-SMYD3 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >15 publications with SMYD3 and Liver
 Muscle Antibodies  >10 publications with SMYD3 and Muscle
 Heart Antibodies  >8 publications with SMYD3 and Heart
 Lung Antibodies  >8 publications with SMYD3 and Lung
 Prostate Antibodies  >5 publications with SMYD3 and Prostate
 Lymph Node Antibodies  >4 publications with SMYD3 and Lymph Node
 Embryonic Tissue Antibodies  >2 publications with SMYD3 and Embryonic Tissue
 Bone Marrow Antibodies  >1 publications with SMYD3 and Bone Marrow
 Vascular Antibodies  >1 publications with SMYD3 and Vascular
 Blood Antibodies  >1 publications with SMYD3 and Blood
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