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14.3.3 gamma Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS835876

MBS835876 is a recombinant protein targeting 14.3.3 gamma. Also known as 14.3.3 gamma protein. Host: Human. Purified recombinant Human 14.3.3 gamma protein More details

$740 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
14.3.3 gamma, Recombinant Protein
Full Product Name
14.3.3 gamma protein
Product Gene Name
14.3.3 gamma recombinant protein
Product Synonym Names
14.3.3 gamma; 14-3-3 gamma; gamma polypeptide 14 3 3 protein gamma protein; 14/3/3 gamma protein; KCIP 1 protein; Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein protein; 14 3 3gamma protein; KCIP1 protein; 14-3-3 gamma protein; Tyrosine 3-monooxygenase/ tryptophan 5-monooxygenase activation protein protein; Protein kinase C inhibitor protein 1 protein; 14 3 3 protein gamma subtype protein; Tyrosine 3 monooxygenase/tryptophan 5 monooxygenase activation protein gamma polypeptide.; 3 monooxygenase/tryptophan 5 monooxgenase activation protein gamma polypeptide protein; 14/3/3 gamma; gamma polypeptide protein; YWHAG protein
Sequence
1-247 amino acids: MVDREQLVQK ARLAEQAERY DDMAAAMKNV TELNEPLSNE ERNLLSVAYK NVVGARRSSW RVISSIEQKT SADGNEKKIE MVRAYREKIE KELEAVCQDV LSLLDNYLIK NCSETQYESK VFYLKMKGDY YRYLAEVATG EKRATVVESS EKAYSEAHEI SKEHMQPTHP IRLGLALNYS VFYYEIQNAP EQACHLAKTA FDDAIAELDT LNEDSYKDST LIMQLLRDNL TLWTSDQQDD DGGEGNN
Host
Human
Form/Format
Supplied as a liquid in 20mM Tris, pH 7.4.
Purity/Purification
> 95% pure
Concentration
1 mg/ml (lot specific)
Preparation and Storage
Store at 4 degree C for short term storage (1/2 weeks). Aliquot and store at -20 degree C or - 70 degree C for long term storage. Avoid repeated freeze/thaw cycles.
Molecular Weight
28 kDa (247 aa), confirmed by MALDI-TOF.
OMIM
605356
3D Structure
ModBase 3D Structure for P61981
Protein Type
Recombinant
Endotoxin Levels
< 1.0 EU per ug of protein (determined by LAL method)
Expression System
E Coli

Product Categories/Family for 14.3.3 gamma recombinant protein

Signal Transduction
Applications Tested/Suitable for 14.3.3 gamma recombinant protein
SDS-PAGE

SDS-PAGE of 14.3.3 gamma recombinant protein

Figure annotation denotes ug of protein loaded and % gel used.
14.3.3 gamma Recombinant Protein – Cat# MBS835876

Other Notes

Small volumes of 14.3.3 gamma recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for 14.3.3 gamma. It may not necessarily be applicable to this product.

NCBI GI #
21464101
NCBI GeneID
7532
NCBI Accession #
NP_036611.2
UniProt Primary Accession #
P61981
UniProt Secondary Accession #
O70457; P35214; Q6FH52; Q9UDP2; Q9UN99
UniProt Related Accession #
P61981
GenBank Nucleotide #
NM_012479.3
NCBI Official Full Name
14-3-3 protein gamma
NCBI Official Synonym Full Names
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma
NCBI Official Symbol
YWHAG
NCBI Official Synonym Symbols
PPP1R170; 14-3-3GAMMA
UniProt Protein Name
14-3-3 protein gamma
UniProt Synonym Protein Names
Protein kinase C inhibitor protein 1; KCIP-1
Protein Family
14-3-3 protein
UniProt Gene Name
YWHAG
UniProt Synonym Gene Names
KCIP-1
UniProt Entry Name
1433G_HUMAN
NCBI Protein Information
14-3-3 protein gamma

NCBI Summary for 14.3.3 gamma

This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the rat ortholog. It is induced by growth factors in human vascular smooth muscle cells, and is also highly expressed in skeletal and heart muscles, suggesting an important role for this protein in muscle tissue. It has been shown to interact with RAF1 and protein kinase C, proteins involved in various signal transduction pathways. [provided by RefSeq, Jul 2008]
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UniProt Comments for 14.3.3 gamma

14-3-3 gamma: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Homodimer. Interacts with SAMSN1. Interacts with RAF1, SSH1 and CRTC2/TORC2. Interacts with ABL1 (phosphorylated form); the interaction retains it in the cytoplasm. Interacts with GAB2. Interacts with MDM4 (phosphorylated); negatively regulates MDM4 activity toward TP53. Interacts with PKA-phosphorylated AANAT. Highly expressed in brain, skeletal muscle, and heart. Belongs to the 14-3-3 family.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 7q11.23

Cellular Component: cytoplasmic vesicle membrane; focal adhesion; membrane; cytosol

Molecular Function: protein kinase C inhibitor activity; protein domain specific binding; insulin-like growth factor receptor binding; protein binding; protein kinase C binding; receptor tyrosine kinase binding

Biological Process: cellular response to insulin stimulus; regulation of neuron differentiation; apoptosis; organelle organization and biogenesis; negative regulation of protein kinase activity; regulation of synaptic plasticity; regulation of signal transduction; mitotic cell cycle; G2/M transition of mitotic cell cycle; protein targeting
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Research Articles on 14.3.3 gamma

1. These results showed that the cell surface expression of TRPM4 channels is mediated by 14-3-3gamma binding.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with 14.3.3 gamma recombinant protein

 Products by Pathway  Pathway Diagram
 Activation Of BAD And Translocation To Mitochondria Pathway antibodies  Activation Of BAD And Translocation To Mitochondria Pathway Diagram
 Activation Of BH3-only Proteins Pathway antibodies  Activation Of BH3-only Proteins Pathway Diagram
 Anchoring Of The Basal Body To The Plasma Membrane Pathway antibodies  Anchoring Of The Basal Body To The Plasma Membrane Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Assembly Of The Primary Cilium Pathway antibodies  Assembly Of The Primary Cilium Pathway Diagram
 Calcium Regulation In The Cardiac Cell Pathway antibodies  Calcium Regulation In The Cardiac Cell Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Checkpoints Pathway antibodies  Cell Cycle Checkpoints Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram

Diseases associated with 14.3.3 gamma recombinant protein

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >5 publications with 14.3.3 gamma and Nervous System Diseases
 Neurobehavioral Manifestations Antibodies  >4 publications with 14.3.3 gamma and Neurobehavioral Manifestations
 Brain Diseases Antibodies  >4 publications with 14.3.3 gamma and Brain Diseases
 Congenital Abnormalities Antibodies  >3 publications with 14.3.3 gamma and Congenital Abnormalities
 Cardiovascular Diseases Antibodies  >3 publications with 14.3.3 gamma and Cardiovascular Diseases
 Heart Diseases Antibodies  >3 publications with 14.3.3 gamma and Heart Diseases
 Disease Models, Animal Antibodies  >1 publications with 14.3.3 gamma and Disease Models, Animal
 Learning Disorders Antibodies  >1 publications with 14.3.3 gamma and Learning Disorders
 Hypertrophy Antibodies  >1 publications with 14.3.3 gamma and Hypertrophy
 Necrosis Antibodies  >1 publications with 14.3.3 gamma and Necrosis

Organs/Tissues associated with 14.3.3 gamma recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >6 publications with 14.3.3 gamma and Brain
 Heart Antibodies  >3 publications with 14.3.3 gamma and Heart
 Bone Antibodies  >3 publications with 14.3.3 gamma and Bone
 Muscle Antibodies  >3 publications with 14.3.3 gamma and Muscle
 Nerve Antibodies  >3 publications with 14.3.3 gamma and Nerve
 Bone Marrow Antibodies  >2 publications with 14.3.3 gamma and Bone Marrow
 Connective Tissue Antibodies  >1 publications with 14.3.3 gamma and Connective Tissue
 Blood Antibodies  >1 publications with 14.3.3 gamma and Blood
 Lung Antibodies  >1 publications with 14.3.3 gamma and Lung
 Kidney Antibodies  >1 publications with 14.3.3 gamma and Kidney
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