Figure annotation denotes ug of protein loaded and % gel used.

Thioredoxin1 (TXN) Active Protein

Name: TXN Active Protein; Thioredoxin1; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS835906
Price: 570 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS835906

MBS835906 is an active protein targeting TXN. Also known as Thioredoxin1 protein. Host: Human. Purified recombinant Human Thioredoxin1 protein More details

$570 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Thioredoxin1 (TXN), Active Protein

Full Product Name

Thioredoxin1 protein

Product Gene Name

TXN active protein

Product Synonym Names

ATL derived factor protein; TXN protein protein; Thioredoxin 1 protein; TR-I protein; TRX1 protein; TXN protein; TRX protein; DKFZp686B1993 protein; Thioredoxin1; Surface associated sulphydryl protein protein; Thioredoxin protein; Thioredoxin -1 protein; Thioredoxin I protein; TRX 1 protein; Thioredoxin-2 protein; Thioredoxin-1 protein; ADF protein; SASP protein; Thioredoxin 1; TRDX protein; TRX2 protein; MGC61975 protein; Thioredoxin -1

Sequence

MVKQIESKTA FQEALDAAGD KLVVVDFSAT WCGPCKMIKP FFHSLSEKYS NVIFLEVDVD DCQDVASECE VKCMPTFQFF KKGQKVGEFS GANKEKLEAT INELV

Host

Human

Form/Format

Supplied as a liquid in PBS, pH 7.4.

Purity/Purification

> 95% pure

Concentration

1 mg/ml (lot specific)

Preparation and Storage

Store at 4 degree C for short term storage (1/2 weeks). Aliquot and store at -20 degree C or - 70 degree C for long term storage. Avoid repeated freeze/thaw cycles.

Molecular Weight

11.7 kDa (105 aa), confirmed by MALDI-TOF.

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Protein Type

Recombinant

Bioactivity

Specific activity is 7-10 A650/min/mg, obtained by measuring the increase of insulin precipitation in absorbance at 650 nm resulting from the reduction of insulin.

Expression System

E Coli

Product Categories/Family for TXN active protein

Signal Transduction

Applications Tested/Suitable for TXN active protein

SDS-PAGE

Application Notes for TXN active protein

1. Prepare a 1ml reaction cocktail in a suitable container. The final concentrations are 5mM Tris, 63mM sodium phosphate, 1mM DTT, 0.1% (w/v) insulin, 2mM EDTA. 2. Add 4ug of recombinant thioredoxin into reaction cocktail and mix immediately. 3. Incubate at 25 DEG C for 20 minutes. 4. Record the increase in A650nm for 15 minutes

Other Notes

Small volumes of TXN active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TXN. It may not necessarily be applicable to this product.

NCBI GI #

332368598

NCBI GeneID

397581

NCBI Accession #

AEE61373.1

UniProt Secondary Accession #

Q95JF9

UniProt Related Accession #

P82460

NCBI Official Full Name

thioredoxin

NCBI Official Symbol

TXN

NCBI Official Synonym Symbols

TRX1

UniProt Protein Name

Thioredoxin

UniProt Gene Name

TXN

UniProt Synonym Gene Names

Trx

UniProt Entry Name

THIO_PIG

NCBI Protein Information

thioredoxin

UniProt Comments for TXN

Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity ().

Research Articles on TXN

1. single-marker and haplotype analyses revealed significant effects of TXNIP on hot carcass weight, test daily gain, and lifetime daily gain

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with TXN active protein

Reference Product	PubMed Publications
TXNIP active protein	>16 publications with TXN and TXNIP
TXNRD1 active protein	>10 publications with TXN and TXNRD1
SOD1 active protein	>8 publications with TXN and SOD1
RRM2 active protein	>1 publications with TXN and RRM2
TXNRD3 active protein	>1 publications with TXN and TXNRD3
PRDX5 active protein	>1 publications with TXN and PRDX5

Pathways associated with TXN active protein

Products by Pathway	Pathway Diagram
Cellular Senescence Pathway antibodies	Cellular Senescence Pathway Diagram
Cellular Responses To Stress Pathway antibodies	Cellular Responses To Stress Pathway Diagram
Detoxification Of Reactive Oxygen Species Pathway antibodies	Detoxification Of Reactive Oxygen Species Pathway Diagram
Gene Expression Pathway antibodies	Gene Expression Pathway Diagram
Generic Transcription Pathway antibodies	Generic Transcription Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Inflammasomes Pathway antibodies	Inflammasomes Pathway Diagram
Innate Immune System Pathway antibodies	Innate Immune System Pathway Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram
Metabolism Of Nucleotides Pathway antibodies	Metabolism Of Nucleotides Pathway Diagram

Diseases associated with TXN active protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>25 publications with TXN and Inflammation
Death Antibodies	>23 publications with TXN and Death
Lung Diseases Antibodies	>16 publications with TXN and Lung Diseases
Cardiovascular Diseases Antibodies	>15 publications with TXN and Cardiovascular Diseases
Necrosis Antibodies	>14 publications with TXN and Necrosis
Nervous System Diseases Antibodies	>7 publications with TXN and Nervous System Diseases
Lung Neoplasms Antibodies	>7 publications with TXN and Lung Neoplasms
Atherosclerosis Antibodies	>6 publications with TXN and Atherosclerosis
Brain Diseases Antibodies	>5 publications with TXN and Brain Diseases
Liver Diseases Antibodies	>5 publications with TXN and Liver Diseases

Organs/Tissues associated with TXN active protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>42 publications with TXN and Blood
Lung Antibodies	>22 publications with TXN and Lung
Lymph Node Antibodies	>14 publications with TXN and Lymph Node
Muscle Antibodies	>11 publications with TXN and Muscle
Heart Antibodies	>10 publications with TXN and Heart
Liver Antibodies	>10 publications with TXN and Liver
Skin Antibodies	>9 publications with TXN and Skin
Brain Antibodies	>8 publications with TXN and Brain
Intestine Antibodies	>5 publications with TXN and Intestine
Pancreas Antibodies	>5 publications with TXN and Pancreas