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14.3.3 epsilon Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS836421

MBS836421 is a recombinant protein targeting 14.3.3 epsilon. Also known as 14.3.3 epsilon protein. Host: Human. Purified recombinant Human 14.3.3 epsilon protein More details

$965 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
14.3.3 epsilon, Recombinant Protein
Full Product Name
14.3.3 epsilon protein
Product Gene Name
14.3.3 epsilon recombinant protein
Product Synonym Names
FLJ45465 protein; epsilon polypeptide 14 3 3 E protein; 14/3/3 epsilon protein; Tyrosine 3/tryptophan 5 monooxygenase activation protein epsilon polypeptide.; MDCR protein; 14 3 3E protein; KCIP1 protein; YWHAE protein; MDS protein; 14.3.3 epsilon; Tyrosine 3-monooxygenase/ tryptophan 5-monooxygenase activation protein protein; 14-3-3 epsilon protein; epsilon polypeptide protein; 14/3/3 epsilon; 14-3-3 epsilon; Protein kinase C inhibitor protein1 protein; Mitochondrial import stimulation factor L subunit protein; Tyrosine 3/tryptophan 5 -monooxygenase activation protein protein; KCIP-1 protein; KCIP 1 protein
Sequence
1-255 amino acids: MDDREDLVYQ AKLAEQAERY DEMVESMKKV AGMDVELTVE ERNLLSVAYK NVIGARRASW RIISSIEQKE ENKGGEDKLK MIREYRQMVE TELKLICCDI LDVLDKHLIP AANTGESKVF YYKMKGDYHR YLAEFATGND RKEAAENSLV AYKAASDIAM TELPPTHPIR LGLALNFSVF YYEILNSPDR ACRLAKAAFD DAIAELDTLS EESYKDSTLI MQLLRDNLTL WTSDMQGDGE EQNKEALQDV EDENQ
Host
Human
Form/Format
Supplied as a liquid in 20mM Tris, pH 7.5.
Purity/Purification
> 95% pure
Concentration
1 mg/ml (lot specific)
Preparation and Storage
Store at 4 degree C for short term storage (1/2 weeks). Aliquot and store at -20 degree C or - 70 degree C for long term storage. Avoid repeated freeze/thaw cycles.
Molecular Weight
29 kDa (255 aa), confirmed by MALDI-TOF.
OMIM
605066
3D Structure
ModBase 3D Structure for P62258
Protein Type
Recombinant
Expression System
E Coli

Product Categories/Family for 14.3.3 epsilon recombinant protein

Signal Transduction
Applications Tested/Suitable for 14.3.3 epsilon recombinant protein
SDS-PAGE

SDS-PAGE of 14.3.3 epsilon recombinant protein

Figure annotation denotes ug of protein loaded and % gel used.
14.3.3 epsilon Recombinant Protein – Cat# MBS836421

Other Notes

Small volumes of 14.3.3 epsilon recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for 14.3.3 epsilon. It may not necessarily be applicable to this product.

NCBI GI #
5803225
NCBI GeneID
7531
NCBI Accession #
NP_006752.1
UniProt Primary Accession #
P62258
UniProt Secondary Accession #
P29360; P42655; Q4VJB6; Q53XZ5; Q63631; Q7M4R4; B3KY71; D3DTH5
UniProt Related Accession #
P62258
GenBank Nucleotide #
NM_006761.4
NCBI Official Full Name
14-3-3 protein epsilon
NCBI Official Synonym Full Names
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
NCBI Official Symbol
YWHAE
NCBI Official Synonym Symbols
MDS; HEL2; MDCR; KCIP-1; 14-3-3E
UniProt Protein Name
14-3-3 protein epsilon
Protein Family
1-acyl-sn-glycerol-3-phosphate acyltransferase
UniProt Gene Name
YWHAE
UniProt Synonym Gene Names
14-3-3E
UniProt Entry Name
1433E_HUMAN
NCBI Protein Information
14-3-3 protein epsilon

NCBI Summary for 14.3.3 epsilon

This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene. [provided by RefSeq, Aug 2008]
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UniProt Comments for 14.3.3 epsilon

14-3-3 epsilon: a protein of the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. A multifunctional regulator of the cell signaling processes.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 17p13.3

Cellular Component: kinesin complex; cytoplasmic vesicle membrane; focal adhesion; membrane; mitochondrion; axon; melanosome; cytosol

Molecular Function: protein domain specific binding; protein binding; enzyme binding; potassium channel regulator activity; protein heterodimerization activity; histone deacetylase binding; phosphoprotein binding; phosphoserine binding

Biological Process: nerve growth factor receptor signaling pathway; viral reproduction; apoptosis; organelle organization and biogenesis; hippocampus development; neuron migration; regulation of caspase activity; regulation of the rate of heart contraction by hormone; substantia nigra development; mitotic cell cycle; cerebral cortex development; G2/M transition of mitotic cell cycle; protein targeting

Disease: Miller-dieker Lissencephaly Syndrome
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Research Articles on 14.3.3 epsilon

1. Results suggest a specific role for YWHAE single nucleotide polymorphisms in the pathophysiology of schizophrenia.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with 14.3.3 epsilon recombinant protein

 Products by Pathway  Pathway Diagram
 Activation Of BAD And Translocation To Mitochondria Pathway antibodies  Activation Of BAD And Translocation To Mitochondria Pathway Diagram
 Activation Of BH3-only Proteins Pathway antibodies  Activation Of BH3-only Proteins Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Anchoring Of The Basal Body To The Plasma Membrane Pathway antibodies  Anchoring Of The Basal Body To The Plasma Membrane Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Assembly Of The Primary Cilium Pathway antibodies  Assembly Of The Primary Cilium Pathway Diagram
 Calcium Regulation In The Cardiac Cell Pathway antibodies  Calcium Regulation In The Cardiac Cell Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Checkpoints Pathway antibodies  Cell Cycle Checkpoints Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram

Diseases associated with 14.3.3 epsilon recombinant protein

 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >9 publications with 14.3.3 epsilon and Brain Diseases
 Classical Lissencephalies and Subcortical Band Heterotopias Antibodies  >8 publications with 14.3.3 epsilon and Classical Lissencephalies and Subcortical Band Heterotopias
 Cardiovascular Diseases Antibodies  >6 publications with 14.3.3 epsilon and Cardiovascular Diseases
 Heart Diseases Antibodies  >5 publications with 14.3.3 epsilon and Heart Diseases
 Kidney Diseases Antibodies  >5 publications with 14.3.3 epsilon and Kidney Diseases
 Heart Defects, Congenital Antibodies  >5 publications with 14.3.3 epsilon and Heart Defects, Congenital
 Necrosis Antibodies  >5 publications with 14.3.3 epsilon and Necrosis
 Adenocarcinoma Antibodies  >4 publications with 14.3.3 epsilon and Adenocarcinoma
 Inflammation Antibodies  >3 publications with 14.3.3 epsilon and Inflammation
 Carcinoma, Hepatocellular Antibodies  >2 publications with 14.3.3 epsilon and Carcinoma, Hepatocellular

Organs/Tissues associated with 14.3.3 epsilon recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >28 publications with 14.3.3 epsilon and Brain
 Heart Antibodies  >9 publications with 14.3.3 epsilon and Heart
 Kidney Antibodies  >7 publications with 14.3.3 epsilon and Kidney
 Nerve Antibodies  >6 publications with 14.3.3 epsilon and Nerve
 Uterus Antibodies  >6 publications with 14.3.3 epsilon and Uterus
 Blood Antibodies  >6 publications with 14.3.3 epsilon and Blood
 Vascular Antibodies  >5 publications with 14.3.3 epsilon and Vascular
 Muscle Antibodies  >5 publications with 14.3.3 epsilon and Muscle
 Liver Antibodies  >4 publications with 14.3.3 epsilon and Liver
 Lymph Node Antibodies  >3 publications with 14.3.3 epsilon and Lymph Node
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