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SET7/9 Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS836527

MBS836527 is a recombinant protein targeting SET7/9. Also known as SET7/9 protein. Host: Human. Purified recombinant Human SET7/9 protein More details

$570 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
SET7/9, Recombinant Protein
Full Product Name
SET7/9 protein
Product Gene Name
SET7/9 recombinant protein
Product Synonym Names
EC 2.1.1.43 protein; SET-7 + SET-9; SET domain-containing protein 7 protein; SET7 + SET9; SET-7 + SET-9 protein; Histone H4-K4 methyltransferase protein; SET 7/9 protein; SET7 protein; SET7/9; SET7/9 protein; SET D7 protein; KIAA1717 protein; Lysine N-methyltransferase 7 protein; SET 7/9; H4 lysine-4 specific protein; SET9 protein; H3 K4 HMTase protein; Histone H3 K4 methyltransferase protein; SET 9 protein; SET-7/9 protein; Histone H3 lysine 4 specific methyltransferase protein; SET-7/9; Histone H3-K4 methyltransferase SETD7 protein; SET domain-containing protein 8 protein; SET domain containing protein 7 protein; H3-K4-HMTase SETD7 protein; SET7 + SET9 protein; KMT7 protein; SETD7 protein; Histone-lysine N-methyltransferase SETD7 protein; Histone lysine N methyltransferase H3 lysine 4 specific SET7 protein; Lysine methyltransferase protein; SET domain-containing protein 7 FLJ21193 protein; Histone-lysine N-methyltransferase protein; SET7/9 Histone methyltransferase protein; SET 7 protein
Sequence
MDSDDEMVEE AVEGHLDDDG LPHGFCTVTY SSTDRFEGNF VHGEKNGRGK FFFFDGSTLE GYYVDDALQG QGVYTYEDGG VLQGTYVDGE LNGPAQEYDT DGRLIFKGQY KDNIRHGVCW IYYPDGGSLV GEVNEDGEMT GEKIAYVYPD ERTALYGKFI DGEMIEGKLA TLMSTEEGRP HFELMPGNSV YHFDKSTSSC ISTNALLPDP YESERVYVAE SLISSAGEGL FSKVAVGPNT VMSFYNGVRI THQEVDSRDW ALNGNTLSLD EETVIDVPEP YNHVSKYCAS LGHKANHSFT PNCIYDMFVH PRFGPIKCIR TLRAVEADEE LTVAYGYDHS PPGKSGPEAP EWYQVELKAF QATQQK
Host
Human
Form/Format
Supplied as a liquid in 50mM Tris-HCl buffer, pH7.5, containing 0.2M NaCl, 5mM DTT, and 20% glycerol.
Purity/Purification
> 95% pure
Concentration
1 mg/ml (lot specific)
Preparation and Storage
Store at 4 degree C for short term storage (1/2 weeks). Aliquot and store at -20 degree C or - 70 degree C for long term storage. Avoid repeated freeze/thaw cycles.
Molecular Weight
40.7 kDa (366 aa), confirmed by MALDI-TOF.
OMIM
606594
3D Structure
ModBase 3D Structure for Q8WTS6
Protein Type
Recombinant
Endotoxin Levels
< 1.0 EU per ug of protein (determined by LAL method)
Expression System
E Coli

Product Categories/Family for SET7/9 recombinant protein

DNA & RNA
Applications Tested/Suitable for SET7/9 recombinant protein
SDS-PAGE

SDS-PAGE of SET7/9 recombinant protein

Figure annotation denotes ug of protein loaded and % gel used.
SET7/9 Recombinant Protein – Cat# MBS836527

Other Notes

Small volumes of SET7/9 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SET7/9. It may not necessarily be applicable to this product.

NCBI GI #
111309205
NCBI GeneID
80854
NCBI Accession #
AAI21056.1
UniProt Primary Accession #
Q8WTS6
UniProt Secondary Accession #
Q0VAH3; Q4W5A9; Q9C0E6; B5WWL3
UniProt Related Accession #
Q8WTS6
NCBI Official Full Name
SET domain containing (lysine methyltransferase) 7
NCBI Official Synonym Full Names
SET domain containing (lysine methyltransferase) 7
NCBI Official Symbol
SETD7
NCBI Official Synonym Symbols
KMT7; SET7; SET9; SET7/9
UniProt Protein Name
Histone-lysine N-methyltransferase SETD7
UniProt Synonym Protein Names
Histone H3-K4 methyltransferase SETD7; H3-K4-HMTase SETD7; Lysine N-methyltransferase 7; SET domain-containing protein 7; SET7/9
Protein Family
Histone-lysine N-methyltransferase
UniProt Gene Name
SETD7
UniProt Synonym Gene Names
KIAA1717; KMT7; SET7; SET9; H3-K4-HMTase SETD7
UniProt Entry Name
SETD7_HUMAN
NCBI Protein Information
histone-lysine N-methyltransferase SETD7

UniProt Comments for SET7/9

SETD7: Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. Interacts with IPF1/PDX-1. Widely expressed. Expressed in pancreatic islets. Belongs to the histone-lysine methyltransferase family. SET7 subfamily.

Protein type: Amino Acid Metabolism - lysine degradation; Methyltransferase; EC 2.1.1.43; Methyltransferase, protein lysine

Chromosomal Location of Human Ortholog: 4q28

Cellular Component: nucleoplasm; nucleolus; chromosome

Molecular Function: protein binding; p53 binding; protein-lysine N-methyltransferase activity; histone-lysine N-methyltransferase activity

Biological Process: establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; regulation of transcription, DNA-dependent; peptidyl-lysine di-methylation; peptidyl-lysine mono-methylation; chromatin modification; response to DNA damage stimulus
Show more

Research Articles on SET7/9

1. Results show that histone-lysine N-methyltransferase Set7 facilitates hepatitis C virus (HCV) replication through the attenuation of interferon-alpha (IFN-alpha) signaling pathways and IFN-related effectors.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with SET7/9 recombinant protein

 Reference Product  PubMed Publications
 SUV39H1 recombinant protein  >6 publications with SET7/9 and SUV39H1
 DNMT1 recombinant protein  >6 publications with SET7/9 and DNMT1
 RELA recombinant protein  >4 publications with SET7/9 and RELA
 SIRT1 recombinant protein  >3 publications with SET7/9 and SIRT1
 TAF10 recombinant protein  >2 publications with SET7/9 and TAF10
 FOXO3 recombinant protein  >2 publications with SET7/9 and FOXO3
 TP53 recombinant protein  >1 publications with SET7/9 and TP53

Pathways associated with SET7/9 recombinant protein

 Products by Pathway  Pathway Diagram
 Chromatin Modifying Enzymes Pathway antibodies  Chromatin Modifying Enzymes Pathway Diagram
 Chromatin Organization Pathway antibodies  Chromatin Organization Pathway Diagram
 FoxO Signaling Pathway antibodies  FoxO Signaling Pathway Diagram
 Lysine Degradation Pathway antibodies  Lysine Degradation Pathway Diagram
 Lysine Degradation Pathway antibodies  Lysine Degradation Pathway Diagram
 PKMTs Methylate Histone Lysines Pathway antibodies  PKMTs Methylate Histone Lysines Pathway Diagram
 P53 Pathway antibodies  P53 Pathway Diagram

Diseases associated with SET7/9 recombinant protein

 Disease Name  Pubmed Publications
 Hyperglycemia Antibodies  >7 publications with SET7/9 and Hyperglycemia
 Disease Models, Animal Antibodies  >4 publications with SET7/9 and Disease Models, Animal
 Inflammation Antibodies  >4 publications with SET7/9 and Inflammation
 Necrosis Antibodies  >3 publications with SET7/9 and Necrosis
 Cell Transformation, Neoplastic Antibodies  >2 publications with SET7/9 and Cell Transformation, Neoplastic
 Liver Cirrhosis Antibodies  >1 publications with SET7/9 and Liver Cirrhosis
 Liver Diseases Antibodies  >1 publications with SET7/9 and Liver Diseases
 Fibrosis Antibodies  >1 publications with SET7/9 and Fibrosis
 Carcinoma, Hepatocellular Antibodies  >1 publications with SET7/9 and Carcinoma, Hepatocellular
 Kidney Diseases Antibodies  >1 publications with SET7/9 and Kidney Diseases

Organs/Tissues associated with SET7/9 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >10 publications with SET7/9 and Heart
 Vascular Antibodies  >8 publications with SET7/9 and Vascular
 Liver Antibodies  >5 publications with SET7/9 and Liver
 Blood Antibodies  >4 publications with SET7/9 and Blood
 Brain Antibodies  >4 publications with SET7/9 and Brain
 Lung Antibodies  >3 publications with SET7/9 and Lung
 Muscle Antibodies  >3 publications with SET7/9 and Muscle
 Kidney Antibodies  >2 publications with SET7/9 and Kidney
 Nerve Antibodies  >2 publications with SET7/9 and Nerve
 Bone Antibodies  >2 publications with SET7/9 and Bone
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