GLRX3 Recombinant Protein – Cat# MBS836807

Figure annotation denotes ug of protein loaded and % gel used.

Glutaredoxin3 (GLRX3) Recombinant Protein

Name: GLRX3 Recombinant Protein; Glutaredoxin3; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS836807
Price: 640 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS836807

MBS836807 is a recombinant protein targeting GLRX3. Also known as Glutaredoxin3 protein (His tag). Host: Human. Purified recombinant Human Glutaredoxin3 protein More details

$640 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Glutaredoxin3 (GLRX3), Recombinant Protein

Full Product Name

Glutaredoxin3 protein (His tag)

Product Gene Name

GLRX3 recombinant protein

Product Synonym Names

Glutaredoxin3; thioredoxin-like 2 protein; Glutaredoxin 3; Glutaredoxin-3; PICOT protein; GLRX3 protein; glutaredoxin 3 protein; Glutaredoxin 3 protein; Thioredoxin-like protein 2 protein; Glutaredoxin-3 protein; GLRX4 protein; GRX4 protein; glutaredoxin 4 protein; bA500G10.4 protein; TXNL2 protein; GRX3 protein

Sequence

1-335 amino acids: MGSSHHHHHH SSGLVPRGSH MAAGAAEAAV AAVEEVGSAG QFEELLRLKA KSLLVVHFWA PWAPQCAQMN EVMAELAKEL PQVSFVKLEA EGVPEVSEKY EISSVPTFLF FKNSQKIDRL DGAHAPELTK KVQRHASSGS FLPSANEHLK EDLNLRLKKL THAAPCMLFM KGTPQEPRCG FSKQMVEILH KHNIQFSSFD IFSDEEVRQG LKAYSSWPTY PQLYVSGELI GGLDIIKELE ASEELDTICP KAPKLEERLK VLTNKASVML FMKGNKQEAK CGFSKQILEI LNSTGVEYET FDILEDEEVR QGLKAYSNWP TYPQLYVKGE LVGGLDIVKE LKENGELLPI LRGEN

Host

Human

Form/Format

Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 10% glycerol and 1mM DTT.

Purity/Purification

> 95% pure

Concentration

0.5 mg/ml (lot specific)

Preparation and Storage

Store at 4 degree C for short term storage (1/2 weeks). Aliquot and store at -20 degree C or - 70 degree C for long term storage. Avoid repeated freeze/thaw cycles.

Molecular Weight

39.6 kDa (355aa), confirmed by MALDI-TOF

OMIM

612754

3D Structure

ModBase 3D Structure for O76003

Protein Type

Recombinant

Expression System

E Coli

Tag/Conjugate

His tag

Product Categories/Family for GLRX3 recombinant protein

Proteases; Inhibitors; & Enzymes; Conjugated Proteins

Applications Tested/Suitable for GLRX3 recombinant protein

SDS-PAGE

Other Notes

Small volumes of GLRX3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for GLRX3. It may not necessarily be applicable to this product.

NCBI GI #

315467838

NCBI GeneID

10539

NCBI Accession #

NP_001186797.1

UniProt Primary Accession #

O76003

UniProt Secondary Accession #

Q5JV01; Q96CE0; Q9P1B0; Q9P1B1; B3KMP7; B3KMQ5; D3DRG2

UniProt Related Accession #

O76003

GenBank Nucleotide #

NM_001199868.1

NCBI Official Full Name

glutaredoxin-3

NCBI Official Synonym Full Names

glutaredoxin 3

NCBI Official Symbol

GLRX3

NCBI Official Synonym Symbols

GRX3; GRX4; GLRX4; PICOT; TXNL2; TXNL3

UniProt Protein Name

Glutaredoxin-3

UniProt Synonym Protein Names

PKC-interacting cousin of thioredoxin; PICOT; PKC-theta-interacting protein; PKCq-interacting protein; Thioredoxin-like protein 2

Protein Family

Glutaredoxin

UniProt Gene Name

GLRX3

UniProt Synonym Gene Names

PICOT; TXNL2; PICOT; PKCq-interacting protein

UniProt Entry Name

GLRX3_HUMAN

NCBI Protein Information

glutaredoxin-3

NCBI Summary for GLRX3

This gene encodes a member of the glutaredoxin family. Glutaredoxins are oxidoreductase enzymes that reduce a variety of substrates using glutathione as a cofactor. The encoded protein binds to and modulates the function of protein kinase C theta. The encoded protein may also inhibit apoptosis and play a role in cellular growth, and the expression of this gene may be a marker for cancer. Pseudogenes of this gene are located on the short arm of chromosomes 6 and 9. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]

UniProt Comments for GLRX3

GLRX3: Critical negative regulator of cardiac hypertrophy and a positive inotropic regulator. May play a role in regulating the function of the thioredoxin system. Does not posses any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity.

Protein type: Oxidoreductase

Chromosomal Location of Human Ortholog: 10q26

Cellular Component: cell cortex; Z disc

Molecular Function: protein binding; protein kinase C binding; electron carrier activity; metal ion binding; protein disulfide oxidoreductase activity; iron-sulfur cluster binding

Biological Process: cell redox homeostasis; regulation of the force of heart contraction

Research Articles on GLRX3

1. Data indicate that silencing of Grx3 in HeLa cells decreases the activities of several cytosolic Fe/S proteins, including iron-regulatory protein 1, a major component of posttranscriptional iron regulation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with GLRX3 recombinant protein

Reference Product	PubMed Publications
PRKCQ recombinant protein	>2 publications with GLRX3 and PRKCQ
TXNRD1 recombinant protein	>1 publications with GLRX3 and TXNRD1
GLRX2 recombinant protein	>1 publications with GLRX3 and GLRX2
GLRX recombinant protein	>1 publications with GLRX3 and GLRX

Diseases associated with GLRX3 recombinant protein

Disease Name	Pubmed Publications
Hypertrophy Antibodies	>3 publications with GLRX3 and Hypertrophy
Neoplasm Metastasis Antibodies	>2 publications with GLRX3 and Neoplasm Metastasis
Liver Neoplasms Antibodies	>2 publications with GLRX3 and Liver Neoplasms
Liver Diseases Antibodies	>1 publications with GLRX3 and Liver Diseases
Heart Diseases Antibodies	>1 publications with GLRX3 and Heart Diseases
Abnormalities, Drug-Induced Antibodies	>1 publications with GLRX3 and Abnormalities, Drug-Induced
Carcinoma, Hepatocellular Antibodies	>1 publications with GLRX3 and Carcinoma, Hepatocellular
Cardiomegaly Antibodies	>1 publications with GLRX3 and Cardiomegaly

Organs/Tissues associated with GLRX3 recombinant protein

Organ/Tissue Name	Pubmed Publications
Lung Antibodies	>3 publications with GLRX3 and Lung
Blood Antibodies	>3 publications with GLRX3 and Blood
Brain Antibodies	>3 publications with GLRX3 and Brain
Kidney Antibodies	>2 publications with GLRX3 and Kidney
Liver Antibodies	>2 publications with GLRX3 and Liver
Pancreas Antibodies	>1 publications with GLRX3 and Pancreas
Lymph Antibodies	>1 publications with GLRX3 and Lymph
Vascular Antibodies	>1 publications with GLRX3 and Vascular
Bladder Antibodies	>1 publications with GLRX3 and Bladder
Embryonic Tissue Antibodies	>1 publications with GLRX3 and Embryonic Tissue