MSK2 Antibody – Rabbit Polyclonal

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including CREB1 and c-fos. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]

MSK2: an AGC kinase of the RSK family. Has two kinase domains connected by a regulatory linker region. Phosphorylates H3 and HMG-14 in response to growth factors and cellular stress.

Protein type: Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Kinase, protein; AGC group; RSK family; MSK subfamily

Chromosomal Location of Human Ortholog: 11q11-q13

Cellular Component: nucleoplasm; cytoplasm; nucleus

Molecular Function: protein serine/threonine kinase activity; protein binding; mitogen-activated protein kinase p38 binding; magnesium ion binding; ribosomal protein S6 kinase activity; ATP binding

Biological Process: axon guidance; positive regulation of histone phosphorylation; regulation of transcription, DNA-dependent; histone phosphorylation; negative regulation of cytokine production; activation of CREB transcription factor; positive regulation of histone acetylation; positive regulation of transcription from RNA polymerase II promoter; inflammatory response; protein amino acid phosphorylation; activation of NF-kappaB transcription factor