RPH3A Antibody – Rabbit Polyclonal

Exocytosis of neurotransmitters and hormones is fundamental to synaptic neurotransmission and cell-cell communication. RAB3A (MIM 179390) is a small G protein that is thought to act at late stages of exocytosis, and RPH3A is a RAB3A effector (Lin et al., 2007 [PubMed 17149709]).[supplied by OMIM, Jul 2008]

rabphilin 3A: Protein transport. Probably involved with Ras-related protein Rab-3A in synaptic vesicle traffic and/or synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Vesicle

Chromosomal Location of Human Ortholog: 12q24.13

Cellular Component: Golgi apparatus; synaptic vesicle; neuron projection; protein complex; extrinsic to membrane; synaptic vesicle membrane; synapse; cytosol; cell junction; secretory granule

Molecular Function: selenium binding; protein binding; phosphatidylinositol-4,5-bisphosphate binding; calcium-dependent phospholipid binding; zinc ion binding; transporter activity; protein complex binding; calcium ion binding; phosphate binding; Rab GTPase binding

Biological Process: intracellular protein transport