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MMAB Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS838082

MBS838082 is an antibody targeting MMAB. Also known as MMAB antibody. Host: Mouse. Mouse monoclonal MMAB antibody More details

$1625 / 0.1 mL +2 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
MMAB, Monoclonal Antibody
Full Product Name
MMAB antibody
Product Gene Name
anti-MMAB antibody
Product Synonym Names
Monoclonal MMAB; Anti-MMAB; Methylmalonic aciduria cblB type; cblB; Cob(I)alamin adenosyltransferase; Methylmalonic aciduria type B protein; ATR; MGC20496
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
4D12
Host
Mouse
Form/Format
Supplied in PBS buffer, pH 7.3, containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration
0.91 mg/ml (lot specific)
Preparation and Storage
Store at -20°C, stable for 12 months from date of receipt.
OMIM
251110
Cross-Reactivity
Human, Mouse, Rat
Immunogen
Full length human recombinant protein of human MMAB (NP_443077) produced in HEK293T cell

Product Categories/Family for anti-MMAB antibody

Proteases; Inhibitors; & Enzymes
Applications Tested/Suitable for anti-MMAB antibody
Flow Cytometry (FC), Immunofluorescence (IF), Western Blot (WB)
Application Notes for anti-MMAB antibody
FC: 1:100
IF: 1:100
WB: 1:2000

Flow Cytometry (FC/FACS) of anti-MMAB antibody

Flow Cytometric analysis of HEK293T cells transfected with either recombinant MMAB protein (red) or empty vector (blue) stained using MMAB antibody
Mouse Anti-MMAB Monoclonal Antibody – Cat# MBS838082

Western Blot (WB) of anti-MMAB antibody

Western Blot analysis of HEK293T cell lysates (5 ug) transfected with either recombinant MMAB protein (Right) or empty vector (Left) detected with MMAB antibody
Mouse Anti-MMAB Monoclonal Antibody, Western Blot (WB) – Cat# MBS838082

Immunofluorescence (IF) of anti-MMAB antibody

Immunofluorescent staining of COS7 cells transiently transfected with recombinant MMAB protein using MMAB antibody
Mouse Anti-MMAB Monoclonal Antibody, Immunofluorescence (IF) – Cat# MBS838082

Other Notes

Small volumes of anti-MMAB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for MMAB. It may not necessarily be applicable to this product.

NCBI GI #
823673820
NCBI GeneID
326625
NCBI Accession #
AKI72121.1
UniProt Secondary Accession #
Q9BSH0; C5HU05
UniProt Related Accession #
Q96EY8
NCBI Official Full Name
MMAB, partial
NCBI Official Synonym Full Names
methylmalonic aciduria (cobalamin deficiency) cblB type
NCBI Official Symbol
MMAB
NCBI Official Synonym Symbols
ATR; cob; cblB; CFAP23
UniProt Protein Name
Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial
UniProt Synonym Protein Names
Cob(I)alamin adenosyltransferase; Methylmalonic aciduria type B protein
UniProt Gene Name
MMAB
UniProt Entry Name
MMAB_HUMAN
NCBI Protein Information
cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial

NCBI Summary for MMAB

This gene encodes a protein that catalyzes the final step in the conversion of vitamin B(12) into adenosylcobalamin (AdoCbl), a vitamin B12-containing coenzyme for methylmalonyl-CoA mutase. Mutations in the gene are the cause of vitamin B12-dependent methylmalonic aciduria linked to the cblB complementation group. Alternatively spliced transcript variants have been found. [provided by RefSeq, Apr 2011]
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UniProt Comments for MMAB

MMAB: Defects in MMAB are the cause of methylmalonic aciduria type cblB (MMAB); also known as methylmalonic aciduria type B or vitamin B12-responsive methylmalonicaciduria of cblB complementation type. MMAB is a disorder of methylmalonate and cobalamin metabolism due to defective synthesis of adenosylcobalamin. Inheritance is autosomal recessive. Belongs to the Cob(I)alamin adenosyltransferase family.

Protein type: Transferase; Motility/polarity/chemotaxis; EC 2.5.1.17; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll

Chromosomal Location of Human Ortholog: 12q24

Cellular Component: mitochondrial matrix

Molecular Function: cob(I)yrinic acid a,c-diamide adenosyltransferase activity; ATP binding

Biological Process: vitamin metabolic process; cobalamin biosynthetic process; cobalamin metabolic process; water-soluble vitamin metabolic process

Disease: Methylmalonic Aciduria, Cblb Type
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Research Articles on MMAB

1. MMAB mutations, including one novel nonsense mutation (c.12 C>A [p.C4X]), were identified in all members of the cblB cohort.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MMAB antibody

 Reference Product  PubMed Publications
 MUT antibody  >8 publications with MMAB and MUT
 MMAA antibody  >7 publications with MMAB and MMAA
 CBL antibody  >3 publications with MMAB and CBL
 MCEE antibody  >2 publications with MMAB and MCEE
 MMACHC antibody  >2 publications with MMAB and MMACHC
 MTRR antibody  >2 publications with MMAB and MTRR
 MMADHC antibody  >1 publications with MMAB and MMADHC

Pathways associated with anti-MMAB antibody

 Products by Pathway  Pathway Diagram
 Cobalamin (Cbl, Vitamin B12) Transport And Metabolism Pathway antibodies  Cobalamin (Cbl, Vitamin B12) Transport And Metabolism Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Vitamins And Cofactors Pathway antibodies  Metabolism Of Vitamins And Cofactors Pathway Diagram
 Metabolism Of Water-soluble Vitamins And Cofactors Pathway antibodies  Metabolism Of Water-soluble Vitamins And Cofactors Pathway Diagram
 Porphyrin And Chlorophyll Metabolism Pathway antibodies  Porphyrin And Chlorophyll Metabolism Pathway Diagram
 Porphyrin And Chlorophyll Metabolism Pathway antibodies  Porphyrin And Chlorophyll Metabolism Pathway Diagram

Diseases associated with anti-MMAB antibody

 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >5 publications with MMAB and Disease Models, Animal
 Methylmalonic aciduria cblB type Antibodies  >5 publications with MMAB and Methylmalonic aciduria cblB type
 Neoplasms, Experimental Antibodies  >2 publications with MMAB and Neoplasms, Experimental
 Breast Neoplasms Antibodies  >2 publications with MMAB and Breast Neoplasms
 Fetal Death Antibodies  >1 publications with MMAB and Fetal Death
 Depressive Disorder Antibodies  >1 publications with MMAB and Depressive Disorder
 Hepatomegaly Antibodies  >1 publications with MMAB and Hepatomegaly
 Kidney Diseases Antibodies  >1 publications with MMAB and Kidney Diseases
 Liver Diseases Antibodies  >1 publications with MMAB and Liver Diseases
 Atrophy Antibodies  >1 publications with MMAB and Atrophy

Organs/Tissues associated with anti-MMAB antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >28 publications with MMAB and Blood
 Liver Antibodies  >9 publications with MMAB and Liver
 Prostate Antibodies  >4 publications with MMAB and Prostate
 Kidney Antibodies  >3 publications with MMAB and Kidney
 Bone Antibodies  >3 publications with MMAB and Bone
 Muscle Antibodies  >3 publications with MMAB and Muscle
 Heart Antibodies  >2 publications with MMAB and Heart
 Bone Marrow Antibodies  >2 publications with MMAB and Bone Marrow
 Placenta Antibodies  >1 publications with MMAB and Placenta
 Intestine Antibodies  >1 publications with MMAB and Intestine
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