GSK3 beta Antibody – Mouse Monoclonal

GSK3B: a proline-directed protein kinase of the GSK family. Phosphorylates and inactivates glycogen synthase. Participates in the Wnt signaling pathway. Involved in energy metabolism, neuronal cell development, and body pattern formation

Protein type: EC 2.7.11.26; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Protein kinase, CMGC; Kinase, protein; CMGC group; GSK family; GSK subfamily

Cellular Component: centrosome; protein complex; dendritic spine; ribonucleoprotein complex; beta-catenin destruction complex; cytosol; lipid raft; nucleoplasm; growth cone; cell soma; membrane; perinuclear region of cytoplasm; cytoplasm; plasma membrane; dendritic shaft; nucleus

Molecular Function: p53 binding; nucleotide binding; beta-catenin binding; transcription factor binding; protein kinase binding; protein kinase activity; transferase activity; integrin binding; protein serine/threonine kinase activity; NF-kappaB binding; ionotropic glutamate receptor binding; protein binding; ubiquitin protein ligase binding; transferase activity, transferring phosphorus-containing groups; tau-protein kinase activity; kinase activity; tau protein binding; ATP binding

Biological Process: fat cell differentiation; circadian rhythm; glycogen metabolic process; negative regulation of MAP kinase activity; re-entry into mitotic cell cycle; genetic imprinting; positive regulation of protein binding; positive regulation of apoptosis; positive regulation of axon extension; protein amino acid autophosphorylation; multicellular organismal development; establishment and/or maintenance of cell polarity; rhythmic process; Wnt receptor signaling pathway through beta-catenin; protein amino acid phosphorylation; positive regulation of protein export from nucleus; protein export from nucleus; cell differentiation; negative regulation of protein binding; positive regulation of cell-matrix adhesion; myoblast fusion; ER overload response; nervous system development; regulation of microtubule-based process; cell migration; Wnt receptor signaling pathway; hippocampus development; myotube differentiation; negative regulation of dendrite morphogenesis; cytoskeleton organization and biogenesis; negative regulation of NFAT protein import into nucleus; positive regulation of peptidyl-serine phosphorylation; negative regulation of signal transduction; cell proliferation; negative regulation of neuron maturation; organ morphogenesis; peptidyl-serine phosphorylation; positive regulation of protein complex assembly; axonogenesis; establishment of cell polarity; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; carbohydrate metabolic process; epithelial to mesenchymal transition; positive regulation of transcription from RNA polymerase II promoter; negative regulation of protein complex assembly; phosphorylation; negative regulation of apoptosis; regulation of neuronal synaptic plasticity