PTPN1 Antibody – Mouse Monoclonal

PTP1B: a non-receptor phospho-tyrosine protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation and inactivation of PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. Negatively regulates insulin signaling by dephosphorylating the phosphotyrosine residues of insulin receptor. Also reported to dephosphorylate integrin, epidermal growth factor receptor, JAK2 and TYK2, regulating cell growth control and the cellular response to interferon. May regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET. PTP1B knockout mice show resistance to dietary weight gain and enhanced insulin sensitivity, suggesting a possible role in treatment of obesity as well as type 2 diabetes.

Protein type: Phosphatase; Protein phosphatase, tyrosine (non-receptor); Motility/polarity/chemotaxis; EC 3.1.3.48

Cellular Component: membrane; endoplasmic reticulum; early endosome; plasma membrane; cytoplasmic vesicle; cytosol

Molecular Function: enzyme binding; ephrin receptor binding; protein phosphatase 2A binding; zinc ion binding; hydrolase activity; phosphoric monoester hydrolase activity; protein tyrosine phosphatase activity; receptor tyrosine kinase binding; protein kinase binding; phosphoprotein phosphatase activity; insulin receptor binding

Biological Process: regulation of insulin receptor signaling pathway; negative regulation of vascular endothelial growth factor receptor signaling pathway; dephosphorylation; unfolded protein response; regulation of endocytosis; actin cytoskeleton reorganization; insulin receptor signaling pathway; regulation of signal transduction; protein amino acid dephosphorylation