FOXO1 pan Antibody – Rabbit Polyclonal

FOXO1A: a transcription factor of the forkhead family. A central regulator of metabolism in several cell types. May play an important role in myogenic growth and differentiation, and in the regulation of lipolysis in adipocytes by controlling the expression of adipose triglyceride lipase (ATGL), the rate-limiting lipolytic enzyme. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma. Contains 1 fork-head domain.

Protein type: Nuclear receptor co-regulator; Transcription factor; Oncoprotein; DNA-binding

Cellular Component: cytoplasm; cytosol; nucleus

Molecular Function: protein binding; DNA binding; protein phosphatase 2A binding; sequence-specific DNA binding; ubiquitin protein ligase binding; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; blood vessel development; transcription, DNA-dependent; apoptosis; positive regulation of apoptosis; positive regulation of transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; cellular response to starvation; glucose homeostasis; negative regulation of stress-activated MAPK cascade; negative regulation of fat cell differentiation; regulation of cell proliferation; regulation of transcription from RNA polymerase II promoter; positive regulation of gluconeogenesis; cellular response to insulin stimulus; regulation of transcription, DNA-dependent; insulin receptor signaling pathway; positive regulation of protein catabolic process; autophagy; positive regulation of transcription from RNA polymerase II promoter; cell differentiation; response to DNA damage stimulus; positive regulation of autophagy; negative regulation of apoptosis