GAL3ST3 Antibody – Rabbit Polyclonal

This gene encodes a member of the galactose-3-O-sulfotransferase protein family. The product of this gene catalyzes sulfonation by transferring a sulfate group to the 3' position of galactose in N-acetyllactosamine in both type 2 (Gal-beta-1-4GlcNAc-R) oligosaccharides and core-2-branched O-glycans, but not on type 1 or core-1-branched structures. This gene, which has also been referred to as GAL3ST2, is different from the GAL3ST2 gene located on chromosome 2 that encodes a related enzyme with distinct tissue distribution and substrate specificities, compared to galactose-3-O-sulfotransferase 3. [provided by RefSeq, Jul 2008]

GAL3ST3: Transfers a sulfate to position 3 of non-reducing beta- galactosyl residues in N-glycans and core2-branched O-glycans. Has high activity towards Gal-beta-1,4-GlcNAc, Gal-beta-1,4(Fuc-alpha- 1,3)GlcNAc and lower activity towards Gal-beta-1,3(Fuc-alpha- 1,4)GlcNAc. Belongs to the galactose-3-O-sulfotransferase family.

Protein type: Transferase; Membrane protein, integral; EC 2.8.2.-

Chromosomal Location of Human Ortholog: 11q13.1

Cellular Component: integral to membrane

Molecular Function: galactosylceramide sulfotransferase activity; 3'-phosphoadenosine 5'-phosphosulfate binding; proteoglycan sulfotransferase activity; galactose 3-O-sulfotransferase activity; carbohydrate binding

Biological Process: sulfur metabolic process; proteoglycan biosynthetic process; oligosaccharide metabolic process; monosaccharide metabolic process; poly-N-acetyllactosamine metabolic process