B3GALNT1 Antibody – Rabbit Polyclonal

This gene is a member of the beta-1,3-galactosyltransferase (beta3GalT) gene family. This family encodes type II membrane-bound glycoproteins with diverse enzymatic functions using different donor substrates (UDP-galactose and UDP-N-acetylglucosamine) and different acceptor sugars (N-acetylglucosamine, galactose, N-acetylgalactosamine). The beta3GalT genes are distantly related to the Drosophila Brainiac gene and have the protein coding sequence contained in a single exon. The beta3GalT proteins also contain conserved sequences not found in the beta4GalT or alpha3GalT proteins. The carbohydrate chains synthesized by these enzymes are designated as type 1, whereas beta4GalT enzymes synthesize type 2 carbohydrate chains. The ratio of type 1:type 2 chains changes during embryogenesis. By sequence similarity, the beta3GalT genes fall into at least two groups: beta3GalT4 and 4 other beta3GalT genes (beta3GalT1-3, beta3GalT5). The encoded protein of this gene does not use N-acetylglucosamine as an acceptor sugar at all. Multiple transcript variants that are alternatively spliced in the 5' UTR have been described; they all encode the same protein. [provided by RefSeq, Jul 2008]

B3GALT3: Transfers N-acetylgalactosamine onto globotriaosylceramide. Belongs to the glycosyltransferase 31 family.

Protein type: Transferase; Membrane protein, integral; Glycan Metabolism - glycosphingolipid biosynthesis - globo series; EC 2.4.1.79

Chromosomal Location of Human Ortholog: 3q25

Cellular Component: Golgi membrane; integral to membrane

Molecular Function: UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity; galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity

Biological Process: oligosaccharide biosynthetic process; protein amino acid glycosylation

Disease: Blood Group, Globoside System; Blood Group, P1pk System