Mouse Anti-TXNRD1 Monoclonal Antibody – Cat# MBS840009

Thioredoxin Reductase 1 (TXNRD1) Antibody – Mouse Monoclonal

Name: TXNRD1 Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS840009
Price: 460 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS840009

Monoclonal Antibody to detect thioredoxin reductase I in human samples.Background: The mammalian thioredoxin reductases (TrxRs) are a family of seleno-cysteine containing pyridine nucleotide-disulfide oxido-reductases. All the mammalian TrxRs are homologous… More details

DISCONTINUED
Click here to view our similar product(s) OR click here to contact our technical support team for suitable replacement.

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

Thioredoxin Reductase 1 (TXNRD1), Monoclonal Antibody

Full Product Name

Thioredoxin Reductase 1 Antibody (19A1)

Product Gene Name

anti-TXNRD1 antibody

Product Synonym Names

Thioredoxin Reductase; GRIM-12; MGC9145; TR; TR1; TRXR1; TXNR.

Clonality

Monoclonal

Isotype

IgG 1

Clone Number

19A1

Host

Mouse

Species Reactivity

Human

Form/Format

100 ul of antibody in HEPES with 0.15 M NaCl, 0.01 % BSA, 0.03 % sodium azide, and 50 % glycerol
Appearance: Colorless liquid

Purity/Purification

Ammonium sulphate precipitation purified antibody

Concentration

1 mg/ml (lot specific)

Preparation and Storage

At -20 degree C
Shelf Life: 12 months

Molecular Weight

50,873 Da

OMIM

601112

3D Structure

ModBase 3D Structure for Q16881

Immunogen

Recombinant human protein purified from E.coli

Positive Control

WB analysis of HeLa and Jurkat cell lysates.

Handling

The antibody solution should be gently mixed before use.

Product Categories/Family for anti-TXNRD1 antibody

Signal Transduction; Signal Transduction Antibodies (A-Z) Antibodies & Supporting Tools; Primary Antibodies (A-Z)

Applications Tested/Suitable for anti-TXNRD1 antibody

Western Blot (WB), ELISA (EIA)

Application Notes for anti-TXNRD1 antibody

Western blot: 1:1000, IP: 1-2 ul, ELISA.

Other Notes

Small volumes of anti-TXNRD1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TXNRD1 purchase

MBS840009 is an antibody targeting TXNRD1. Also known as Thioredoxin Reductase 1 Antibody (19A1). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for TXNRD1. It may not necessarily be applicable to this product.

NCBI GI #

148277071

NCBI GeneID

7296

NCBI Accession #

NP_001087240.1

UniProt Primary Accession #

Q16881

UniProt Secondary Accession #

Q6FI31; Q6VB40; Q6VB41; Q6VB42; Q6VBP2; Q6VBP3; B7Z1F4; B7Z3Y8; B7Z904; E9PMY9; F5H780

UniProt Related Accession #

Q16881

GenBank Nucleotide #

NM_001093771.2

NCBI Official Full Name

thioredoxin reductase 1, cytoplasmic isoform 3

NCBI Official Synonym Full Names

thioredoxin reductase 1

NCBI Official Symbol

TXNRD1

NCBI Official Synonym Symbols

TR; TR1; TXNR; TRXR1; GRIM-12

UniProt Protein Name

Thioredoxin reductase 1, cytoplasmic

UniProt Synonym Protein Names

Gene associated with retinoic and interferon-induced mortality 12 protein; GRIM-12; Gene associated with retinoic and IFN-induced mortality 12 protein; KM-102-derived reductase-like factor; Thioredoxin reductase TR1

Protein Family

Thioredoxin reductase

UniProt Gene Name

TXNRD1

UniProt Synonym Gene Names

GRIM12; KDRF; TR; GRIM-12; Gene associated with retinoic and IFN-induced mortality 12 protein

UniProt Entry Name

TRXR1_HUMAN

NCBI Protein Information

thioredoxin reductase 1, cytoplasmic

NCBI Summary for TXNRD1

This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine (Sec) residue which is required for catalytic activity. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenocysteine-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in several transcript variants encoding the same or different isoforms. [provided by RefSeq, Jul 2008]

UniProt Comments for TXNRD1

TRXR1: a cytoplasmic pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine residue which is required for the catalytic activity.

Protein type: EC 1.8.1.9; Nuclear receptor co-regulator; Nucleotide Metabolism - pyrimidine; Oxidoreductase

Chromosomal Location of Human Ortholog: 12q23-q24.1

Cellular Component: nucleoplasm; nucleolus; cytosol

Molecular Function: protein binding; thioredoxin-disulfide reductase activity; FAD binding; electron carrier activity; protein disulfide oxidoreductase activity

Biological Process: response to reactive oxygen species; nucleobase, nucleoside and nucleotide metabolic process; nucleobase, nucleoside and nucleotide interconversion; cell redox homeostasis; cellular lipid metabolic process; signal transduction

Research Articles on TXNRD1

1. Thioredoxin reductase 1 (TrxR1) protein levels and activity were inducible up to 2.2-fold by selenium.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-TXNRD1 antibody

Products by Pathway	Pathway Diagram
Cellular Responses To Stress Pathway antibodies	Cellular Responses To Stress Pathway Diagram
Detoxification Of Reactive Oxygen Species Pathway antibodies	Detoxification Of Reactive Oxygen Species Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies	Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
Gene Expression Pathway antibodies	Gene Expression Pathway Diagram
Generic Transcription Pathway antibodies	Generic Transcription Pathway Diagram
Infectious Disease Pathway antibodies	Infectious Disease Pathway Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram
Metabolism Of Lipids And Lipoproteins Pathway antibodies	Metabolism Of Lipids And Lipoproteins Pathway Diagram
Metabolism Of Nucleotides Pathway antibodies	Metabolism Of Nucleotides Pathway Diagram

Diseases associated with anti-TXNRD1 antibody

Disease Name	Pubmed Publications
Liver Diseases Antibodies	>20 publications with TXNRD1 and Liver Diseases
Neoplasms, Experimental Antibodies	>14 publications with TXNRD1 and Neoplasms, Experimental
Breast Neoplasms Antibodies	>13 publications with TXNRD1 and Breast Neoplasms
Nervous System Diseases Antibodies	>13 publications with TXNRD1 and Nervous System Diseases
Cardiovascular Diseases Antibodies	>12 publications with TXNRD1 and Cardiovascular Diseases
Liver Neoplasms Antibodies	>11 publications with TXNRD1 and Liver Neoplasms
Inflammation Antibodies	>10 publications with TXNRD1 and Inflammation
Lung Diseases Antibodies	>10 publications with TXNRD1 and Lung Diseases
Necrosis Antibodies	>9 publications with TXNRD1 and Necrosis
Poisoning Antibodies	>9 publications with TXNRD1 and Poisoning

Organs/Tissues associated with anti-TXNRD1 antibody

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>48 publications with TXNRD1 and Liver
Blood Antibodies	>23 publications with TXNRD1 and Blood
Lung Antibodies	>20 publications with TXNRD1 and Lung
Brain Antibodies	>14 publications with TXNRD1 and Brain
Kidney Antibodies	>13 publications with TXNRD1 and Kidney
Heart Antibodies	>13 publications with TXNRD1 and Heart
Muscle Antibodies	>13 publications with TXNRD1 and Muscle
Prostate Antibodies	>10 publications with TXNRD1 and Prostate
Skin Antibodies	>9 publications with TXNRD1 and Skin
Vascular Antibodies	>9 publications with TXNRD1 and Vascular