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Proteinase Inhibitor 9 (Pi-9) (SERPINB9) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS840015

Background: Proteinase inhibitor 9 (PI-9, also designated cytoplasmic antiproteinase 3, or CAP3) is a 42 kDa member of the ovalbumin family of serpins that is expressed in placenta, lung and cytotoxic lymphocytes. PI-9 is a potent inhibitor of granzyme B and… More details

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Product Overview

Product Name
Proteinase Inhibitor 9 (PI-9) (SERPINB9), Monoclonal Antibody
Full Product Name
Proteinase Inhibitor 9 (PI-9) Antibody (Clone PI9-17)
Product Gene Name
Product Synonym Names
CAP3 CAP3 Cytoplasmic antiase3 PI9 Protease inhibitor9 ovalbumin type Serpin B9 Serine or Cysteine ase Inhibitor
Clonality
Monoclonal
Isotype
IgG1
Clone Number
PI9-17
Host
Mouse
Species Reactivity
Human
Form/Format
100 ug (0.5 mg/ml) mouse monoclonal antibody from culture supernatant diluted in phosphate-buffered saline (PBS) containing 50% glycerol, 1% BSA, and 0.02% thimerosal.
Appearance: Colorless liquid
Purity/Purification
Affinity purified
Concentration
0.5 mg/ml (lot specific)
Preparation and Storage
At -20 degree C
Shelf Life: 12 months
Molecular Weight
42,404 Da
OMIM
601799
3D Structure
ModBase 3D Structure for P50453
Immunogen
Recombinant human full length PI9
Handling
The antibody solution should be gently mixed before use.
Applications Tested/Suitable for anti-SERPINB9 antibody
Western Blot (WB)
Application Notes for anti-SERPINB9 antibody
Western blotting (2-4 ug/ml) and Immunohistochemistry (20 ug/ml). It recognizes 42 kDa native human PI-9 and the 63 kDa PI-9 complexed to granzyme B. Reactivity to other species has not been tested.

Testing Data of anti-SERPINB9 antibody

Mouse Anti-SERPINB9 Monoclonal Antibody – Cat# MBS840015

Other Notes

Small volumes of anti-SERPINB9 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SERPINB9 purchase

MBS840015 is an antibody targeting SERPINB9. Also known as Proteinase Inhibitor 9 (PI-9) Antibody (Clone PI9-17). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for SERPINB9. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
serpin B9
NCBI Official Synonym Full Names
serpin peptidase inhibitor, clade B (ovalbumin), member 9
NCBI Official Symbol
SERPINB9
NCBI Official Synonym Symbols
PI9; CAP3; PI-9; CAP-3
UniProt Protein Name
Serpin B9
UniProt Synonym Protein Names
Cytoplasmic antiproteinase 3; CAP-3; CAP3; Peptidase inhibitor 9; PI-9
Protein Family
UniProt Gene Name
SERPINB9
UniProt Synonym Gene Names
PI9; CAP-3; CAP3; PI-9
UniProt Entry Name
SPB9_HUMAN
NCBI Protein Information
serpin B9

NCBI Summary for SERPINB9

This gene encodes a member of the serine protease inhibitor family which are also known as serpins. The encoded protein belongs to a subfamily of intracellular serpins. This protein inhibits the activity of the effector molecule granzyme B. Overexpression of this protein may prevent cytotoxic T-lymphocytes from eliminating certain tumor cells. A pseudogene of this gene is found on chromosome 6. [provided by RefSeq, Mar 2012]
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UniProt Comments for SERPINB9

SERPINB9: Granzyme B inhibitor. Belongs to the serpin family. Ov-serpin subfamily.

Chromosomal Location of Human Ortholog: 6p25

Cellular Component: extracellular space; membrane; cytoplasm; intracellular; nucleus; cytosol

Molecular Function: serine-type endopeptidase inhibitor activity; protein binding; protease binding; caspase inhibitor activity

Biological Process: mast cell mediated immunity; response to bacterium; immune response; negative regulation of caspase activity; negative regulation by symbiont of host apoptosis; protection from natural killer cell mediated cytotoxicity; negative regulation of apoptosis
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-SERPINB9 antibody

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