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N-Cadherin (CDH2) Antibody – Rabbit Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS840029

Monoclonal Antibody to detect N Cadherin in human samples. Background: Thy1 is a GPI-anchored, developmentally regulated protein involved in various signaling cascades that mediate neurite outgrowth, T cell activation, tumor suppression, apoptosis, and… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Product Name
N-Cadherin (CDH2), Monoclonal Antibody
Full Product Name
N-Cadherin Antibody (Clone # EPR1791-4)
Product Gene Name
anti-CDH2 antibody
Product Synonym Names
CDH2; CDHN; NCAD; Cadherin-2; CDw325
Clonality
Monoclonal
Isotype
IgG
Clone Number
EPR1791-4
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
In 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Appearance: Colorless liquid
Preparation and Storage
At -20 degree C
Shelf Life: 12 months
Molecular Weight
97,040 Da
OMIM
114020
3D Structure
ModBase 3D Structure for P19022
Immunogen
A synthetic peptide corresponding to residues in the extracellular region of human N-Cadherin was used as an immunogen.
Positive Control
Western blot:Huvec, C6 and Hela cell lysates.
Handling
The antibody solution should be gently mixed before use.

Product Categories/Family for anti-CDH2 antibody

Stem Cell Research Tools; AntibodiesAntibodies & Supporting Tools; Antibodies for Stem Cell Research (NEW) Antibodies & Supporting Tools; Primary Antibodies (A-Z)
Applications Tested/Suitable for anti-CDH2 antibody
Western Blot (WB)
Application Notes for anti-CDH2 antibody
WB: 1:1000 - 1:10000.

Other Notes

Small volumes of anti-CDH2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CDH2 purchase

MBS840029 is an antibody targeting CDH2. Also known as N-Cadherin Antibody (Clone # EPR1791-4). Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CDH2. It may not necessarily be applicable to this product.

NCBI GI #
815890961
NCBI GeneID
1000
NCBI Accession #
NP_001295105.1
UniProt Primary Accession #
P19022
UniProt Secondary Accession #
Q14923; Q8N173; A8MWK3; B0YIY6
UniProt Related Accession #
P19022
GenBank Nucleotide #
NM_001308176.1
NCBI Official Full Name
cadherin-2 isoform 2
NCBI Official Synonym Full Names
cadherin 2, type 1, N-cadherin (neuronal)
NCBI Official Symbol
CDH2
NCBI Official Synonym Symbols
CDHN; NCAD; CD325; CDw325
UniProt Protein Name
Cadherin-2
UniProt Synonym Protein Names
CDw325; Neural cadherin; N-cadherin; CD_antigen: CD325
Protein Family
Cadherin
UniProt Gene Name
CDH2
UniProt Synonym Gene Names
CDHN; NCAD; N-cadherin
UniProt Entry Name
CADH2_HUMAN
NCBI Protein Information
cadherin-2

NCBI Summary for CDH2

This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry. At certain central nervous system synapses, presynaptic to postsynaptic adhesion is mediated at least in part by this gene product. [provided by RefSeq, Jul 2008]
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UniProt Comments for CDH2

CDH2: Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density. Interacts with CDCP1. Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Interacts with PCDH8; this complex may also include TAOK2. The interaction with PCDH8 may lead to internalization through TAOK2/p38 MAPK pathway.

Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 18q11.2

Cellular Component: cell-cell adherens junction; focal adhesion; lamellipodium; apical plasma membrane; plasma membrane; integral to membrane; synapse; catenin complex; intercellular junction; fascia adherens

Molecular Function: protein binding; gamma-catenin binding; beta-catenin binding; calcium ion binding; protein phosphatase binding; alpha-catenin binding

Biological Process: heterophilic cell adhesion; intercellular junction assembly and maintenance; cell migration; muscle cell differentiation; glial cell differentiation; positive regulation of MAPKKK cascade; calcium-dependent cell-cell adhesion; blood vessel morphogenesis; striated muscle cell differentiation; positive regulation of muscle cell differentiation; homophilic cell adhesion; cell adhesion
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Research Articles on CDH2

1. Results suggest that N-cadherin may promote motility and invasiveness through distinct mechanisms and that beta-catenin may be an integral mediator of N-cadherin-dependent invasive signaling in oral epithelia.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-CDH2 antibody

 Disease Name  Pubmed Publications
 Neoplasm Metastasis Antibodies  >54 publications with CDH2 and Neoplasm Metastasis
 Disease Progression Antibodies  >35 publications with CDH2 and Disease Progression
 Lung Neoplasms Antibodies  >30 publications with CDH2 and Lung Neoplasms
 Breast Neoplasms Antibodies  >29 publications with CDH2 and Breast Neoplasms
 Cardiovascular Diseases Antibodies  >21 publications with CDH2 and Cardiovascular Diseases
 Liver Neoplasms Antibodies  >17 publications with CDH2 and Liver Neoplasms
 Liver Diseases Antibodies  >16 publications with CDH2 and Liver Diseases
 Heart Diseases Antibodies  >15 publications with CDH2 and Heart Diseases
 Neoplasms, Experimental Antibodies  >15 publications with CDH2 and Neoplasms, Experimental
 Carcinoma, Hepatocellular Antibodies  >14 publications with CDH2 and Carcinoma, Hepatocellular

Organs/Tissues associated with anti-CDH2 antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >58 publications with CDH2 and Muscle
 Brain Antibodies  >52 publications with CDH2 and Brain
 Embryonic Tissue Antibodies  >44 publications with CDH2 and Embryonic Tissue
 Bone Antibodies  >36 publications with CDH2 and Bone
 Vascular Antibodies  >35 publications with CDH2 and Vascular
 Lung Antibodies  >35 publications with CDH2 and Lung
 Heart Antibodies  >34 publications with CDH2 and Heart
 Liver Antibodies  >24 publications with CDH2 and Liver
 Eye Antibodies  >22 publications with CDH2 and Eye
 Prostate Antibodies  >18 publications with CDH2 and Prostate
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