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MI-463

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8400308

MI-463 is a potent inhibitor of Menin-MLL interaction (IC50 = 15.3nM). Pharmacologic inhibition of the menin-mLL interaction substantially delays progression of mLL leukemia in murine models through on-target activity without causing toxicity. MI-463 induces… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Product Name
MI-463, Biochemical
Full Product Name
MI-463
Product Gene Name
MI-463 biochemical
Product Synonym Names
4-methyl-5-((4-((6-(2, 2, 2-trifluoroethyl)thieno[2, 3-d]pyrimidin-4-yl)amino)piperidin-1-yl)methyl)-1H-indole-2-carbonitrile, MI463
Form/Format
Crystalline solid
Purity/Purification
>=98% by HPLC
Specificity
A potent inhibitor of Menin-MLL interaction
Preparation and Storage
Store at -20 degree C
Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Shipping: Gel Pack
Shelf Life: Est.~36 months
Country of Origin: USA
Molecular Weight
484.55
Solubilities
>50mg/ml DMSO
Molecular Formula
C??H??F?N?S
InChi
InChI=1S/C24H23F3N6S/c1-14-15(2-3-21-19(14)8-17(11-28)31-21)12-33-6-4-16(5-7-33)32-22-20-9-18(10-24(25; 26)27)34-23(20)30-13-29-22/h2-3; 8-9; 13; 16; 31H; 4-7; 10; 12H2; 1H3; (H; 29; 30; 32)
InChi Key
DZACSLYTXLZAAF-UHFFFAOYSA-N
SMILES
CC1=C(C=CC2=C1C=C(N2)C#N)CN3CCC(CC3)NC4=C5C=C(SC5=NC=N4)CC(F)(F)F
CAS Number
1628317-18-9
MDL Number
MFCD28506301
PubChem CID
90455046

Product Categories/Family for MI-463 biochemical

Web Categories; Biochemicals; Biochemicals (A-Z); Enzyme Inhibitors; Enzyme Inhibitors (A-Z); Cancer Research; Epigenetic Regulation; Writer Enzymes; DNA Methyltransferases (DNMTs); DNMT Inhibitors; Methyltransferase Inhibitors; Epigenetic Modulators (A-Z

Structure of MI-463 biochemical

MI-463 Biochemical – Cat# MBS8400308

Product References and Citations for MI-463 biochemical

https://pubchem.ncbi.nlm.nih.gov/compound/90455046

Other Notes

Small volumes of MI-463 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MI-463 purchase

MBS8400308 is a biochemical targeting MI-463.
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