Adaptaquin

Adaptaquin is a brain-permeable hypoxia-inducible factor (HIF) prolyl hydroxylase 2 (PHD2) inhibitor. It stabilizes HIF-1alpha protein and induces expression of the HIF-1-regulated genes EPO and VEGF in SH-SY5Y human neuroblastoma cells. Adaptaquin protects against cell death induced by glutathione depletion in rat primary cortical neurons (IC50 = 0.25uM) and reduces glutamate-induced cell death in HT-22 cells. Displays neuroprotective effects and enhances functional recovery in rodent intracerebral hemorrhage models, via inhibition of ATF4 dependent genes. Also acts as an antioxidant.

https://pubchem.ncbi.nlm.nih.gov/compound/3740671

Small volumes of Adaptaquin biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS8400346 is a biochemical targeting Adaptaquin.